{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang F"],"funding":["the National Key Research and Development Program/Prevention and Treatment Research on Commonly Occurring and Prevalent Diseases","the Medicine and Health Technology Innovation Project of the Chinese Academy of Medical Sciences"],"pagination":["618"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11535149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Lateral lymph node dissection (LLND) can decrease local recurrence to lateral compartments in middle-low rectal cancer, but pathological evidence for optimal surgical indications, especially after neoadjuvant (chemo)radiotherapy (nCRT), is lacking. This study aimed to identify the predictive factors and oncological outcomes for different LLN locations associated with pathological metastasis.<h4>Method</h4>In this multicenter study, patients from 19 centers who underwent total mesorectal excision (TME) with LLND for locally advanced mid-/low rectal cancer from January 2012 to December 2021 were included.<h4>Results</h4>All 566 included patients underwent TME with LLND surgery; 241 (37.4%) of the largest LLNs were located in the obturator area, and 403 (62.6%) of the large"],"journal":["Discover oncology"],"pubmed_title":["The diagnosis and oncological outcomes of obturator and internal iliac lymph node metastasis in middle-low rectal cancer: results of a multicenter Lateral Node Collaborative Group study in China."],"pmcid":["PMC11535149"],"funding_grant_id":["No. 2017-12 M-1e006","No. 2022YFC2505003"],"pubmed_authors":["Huang F","Wei R","Xing W","Zhou S","the Chinese Lateral Node Collaborative Group","Mei S","Liu Q","Xiao T"],"additional_accession":[]},"is_claimable":false,"name":"The diagnosis and oncological outcomes of obturator and internal iliac lymph node metastasis in middle-low rectal cancer: results of a multicenter Lateral Node Collaborative Group study in China.","description":"<h4>Background</h4>Lateral lymph node dissection (LLND) can decrease local recurrence to lateral compartments in middle-low rectal cancer, but pathological evidence for optimal surgical indications, especially after neoadjuvant (chemo)radiotherapy (nCRT), is lacking. This study aimed to identify the predictive factors and oncological outcomes for different LLN locations associated with pathological metastasis.<h4>Method</h4>In this multicenter study, patients from 19 centers who underwent total mesorectal excision (TME) with LLND for locally advanced mid-/low rectal cancer from January 2012 to December 2021 were included.<h4>Results</h4>All 566 included patients underwent TME with LLND surgery; 241 (37.4%) of the largest LLNs were located in the obturator area, and 403 (62.6%) of the large","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-04-22T03:22:17.237Z","creation":"2025-04-04T23:31:51.209Z"},"accession":"S-EPMC11535149","cross_references":{"pubmed":["39497010"],"doi":["10.1007/s12672-024-01500-4"]}}