biostudies-literatureSumpio BJNIDDK NIH HHSNIGMS NIH HHS435-445https://www.ebi.ac.uk/biostudies/studies/S-EPMC11535488biostudies-literatureUnknown13(9)<b>Introduction:</b> Diabetes mellitus (DM) affects over 422 million people globally. Patients with DM are subject to a myriad of complications, of which diabetic foot ulcers (DFUs) are the most common with ∼25% chance of developing these wounds throughout their lifetime. <b>Innovation:</b> Currently there are no therapeutic RNAs approved for use in DFUs. Use of dressings containing novel layer-by-layer (LbL)-formulated therapeutic RNAs that inhibit PHD2 and miR-210 can significantly improve diabetic wound healing. These dressings provide sustained release of therapeutic RNAs to the wounds locally without systemic side effects. <b>Clinical Problem Addressed:</b> Diabetic foot wounds are difficult to heal and often result in significant patient morbidity and mortality. <b>Materials and MethAdvances in wound careUse of Therapeutic RNAs to Accelerate Wound Healing in Diabetic Rabbit Wounds.PMC11535488F30 DK130564T32 GM144273Li ZJohnston BHSumpio BJDallas AWang EMezghani IBerger AGIlves HVeves AContreras MHammond PTTheocharidis GfalseUse of Therapeutic RNAs to Accelerate Wound Healing in Diabetic Rabbit Wounds.<b>Introduction:</b> Diabetes mellitus (DM) affects over 422 million people globally. Patients with DM are subject to a myriad of complications, of which diabetic foot ulcers (DFUs) are the most common with ∼25% chance of developing these wounds throughout their lifetime. <b>Innovation:</b> Currently there are no therapeutic RNAs approved for use in DFUs. Use of dressings containing novel layer-by-layer (LbL)-formulated therapeutic RNAs that inhibit PHD2 and miR-210 can significantly improve diabetic wound healing. These dressings provide sustained release of therapeutic RNAs to the wounds locally without systemic side effects. <b>Clinical Problem Addressed:</b> Diabetic foot wounds are difficult to heal and often result in significant patient morbidity and mortality. <b>Materials and Meth2024-01-01T00:00:00Z2024 Sep2026-05-29T18:45:57.027Z2026-04-08T05:43:12.536ZS-EPMC115354883818363110.1089/wound.2023.0056