biostudies-literatureUnknown14(1)Muller MUniversitätsklinikum Hamburg-Eppendorf (UKE)Coronary artery disease (CAD) is characterized by narrowing and subsequent blockade of coronary arteries, and imposes a significant health and economic burden. Stent and scaffold devices are introduced in advanced CAD to improve vascular stability and restore blood flow. Although in vitro flow systems like the Chandler loop have been developed to enhance the understanding of interactions between device materials, their coatings, and vascular cells, imaging-based in vitro analysis of device performance is limited. In this study, we established a novel stent flow chamber system designed to assess the thrombogenicity of bioresorbable magnesium scaffold (RMS) and stent materials in vitro. Additionally, we compared the thrombogenicity - an important clinical parameter in stent performance - of Scientific reports26691https://www.ebi.ac.uk/biostudies/studies/S-EPMC11535548biostudies-literatureA novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.PMC11535548Mailer RKMuller MLudwig LEnglert HFrye MRiedl KABeerens MLang SRenne TBaumann-Zumstein PMuller MCHemkemeyer SAfalseA novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.Coronary artery disease (CAD) is characterized by narrowing and subsequent blockade of coronary arteries, and imposes a significant health and economic burden. Stent and scaffold devices are introduced in advanced CAD to improve vascular stability and restore blood flow. Although in vitro flow systems like the Chandler loop have been developed to enhance the understanding of interactions between device materials, their coatings, and vascular cells, imaging-based in vitro analysis of device performance is limited. In this study, we established a novel stent flow chamber system designed to assess the thrombogenicity of bioresorbable magnesium scaffold (RMS) and stent materials in vitro. Additionally, we compared the thrombogenicity - an important clinical parameter in stent performance - of 2024-01-01T00:00:00Z2024 Nov2025-04-20T03:52:51.165Z2025-04-20T03:52:51.165ZS-EPMC115355483949669810.1038/s41598-024-77266-0