biostudies-literatureUnknown9Rennie O<h4>Background and objective</h4>Hepatobiliary diseases are a longstanding and significant medical challenge which, despite advances in surgical techniques, still carry risks for postoperative complications such as anastomotic leaks (ALs), which can include both postoperative pancreatic fistula (POPF) and bile leaks (BL). These complications incur significant human and economic costs on all those involved, including the patient, healthcare providers, and hospital systems. The aim of this study was to construct a narrative review of literature surrounding definitions and grading systems for ALs in the context of hepato-pancreato-biliary (HPB) procedures, and consequences of POPF and BL.<h4>Methods</h4>A literature review was conducted by examining databases including PubMed, Web of Science,Translational gastroenterology and hepatology70https://www.ebi.ac.uk/biostudies/studies/S-EPMC11535784biostudies-literatureHepatobiliary anastomotic leakage: a narrative review of definitions, grading systems, and consequences of leaks.PMC11535784Rennie OHelwa NSharma MfalseHepatobiliary anastomotic leakage: a narrative review of definitions, grading systems, and consequences of leaks.<h4>Background and objective</h4>Hepatobiliary diseases are a longstanding and significant medical challenge which, despite advances in surgical techniques, still carry risks for postoperative complications such as anastomotic leaks (ALs), which can include both postoperative pancreatic fistula (POPF) and bile leaks (BL). These complications incur significant human and economic costs on all those involved, including the patient, healthcare providers, and hospital systems. The aim of this study was to construct a narrative review of literature surrounding definitions and grading systems for ALs in the context of hepato-pancreato-biliary (HPB) procedures, and consequences of POPF and BL.<h4>Methods</h4>A literature review was conducted by examining databases including PubMed, Web of Science,2024-01-01T00:00:00Z20242026-07-16T13:13:28.071Z2025-04-04T03:05:07.823ZS-EPMC115357843950301810.21037/tgh-24-9