biostudies-literatureUnknown9Jiao N<h4>Background</h4>Liver transplantation (LT) is the most effective and radical treatment for hepatocellular carcinoma (HCC). Most LT criteria are based on the morphological characteristics of tumors, which are not enough to predict the risk of tumor recurrence. It is found that some serological biomarkers can predict tumor recurrence and may be a good indicator for selecting suitable HCC patients for LT. This article aims to evaluate the predictive effect of preoperative serological indicators on long-term overall survival (OS) and tumor recurrence-free survival (TFS) of patients with HCC after LT, and to explore its significance for expanding the Milan criteria.<h4>Methods</h4>Clinical data of 253 patients after LT in HCC were collected retrospectively. The receiver operating characterisTranslational gastroenterology and hepatology63https://www.ebi.ac.uk/biostudies/studies/S-EPMC11535812biostudies-literatureLiver transplantation for hepatocellular carcinoma: a proposal for including preoperative serological indicators improves the Milan criteria expanded.PMC11535812Jiao NZheng ZSYang YOiu SLi CJin HLYan CChen XGHe LZhang QLu BWu FDfalseLiver transplantation for hepatocellular carcinoma: a proposal for including preoperative serological indicators improves the Milan criteria expanded.<h4>Background</h4>Liver transplantation (LT) is the most effective and radical treatment for hepatocellular carcinoma (HCC). Most LT criteria are based on the morphological characteristics of tumors, which are not enough to predict the risk of tumor recurrence. It is found that some serological biomarkers can predict tumor recurrence and may be a good indicator for selecting suitable HCC patients for LT. This article aims to evaluate the predictive effect of preoperative serological indicators on long-term overall survival (OS) and tumor recurrence-free survival (TFS) of patients with HCC after LT, and to explore its significance for expanding the Milan criteria.<h4>Methods</h4>Clinical data of 253 patients after LT in HCC were collected retrospectively. The receiver operating characteris2024-01-01T00:00:00Z20242026-07-16T13:13:36.825Z2025-04-04T03:05:12.861ZS-EPMC115358123950302610.21037/tgh-24-40