{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin L"],"funding":["MOST | National Natural Science Foundation of China (NSFC)","Special Fund for Scientific and Technological Innovation Talent Teams of Shanxi Province","MOST | National Natural Science Foundation of China"],"pagination":["e2409597121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11536148"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(44)"],"pubmed_abstract":["Epidemiological studies show a strong correlation between air pollution and fetal growth restriction (FGR), but existing results are controversial due to inherent limitations, such as causality of specific pollutants, developmental origin, and maternal-fetal transmission. To address this controversy, we first conducted a retrospective analysis of 28,796 newborns and revealed that maternal nitrogen dioxide (NO<sub>2</sub>) exposure during the second trimester was positively associated with FGR, with an adjusted odds ratio of 1.075 (95% confidence interval: 1.020-1.133) per 10 μg/m<sup>3</sup> NO<sub>2</sub> increase for small for gestational age. Then, by establishing an animal model of prenatal NO<sub>2</sub> exposure, we confirmed its adverse effects on embryonic growth and hematopoiesis "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Maternal NO&lt;sub&gt;2&lt;/sub&gt; exposure and fetal growth restriction: Hypoxia transmission and lncRNAs-proinflammation-mediated abnormal hematopoiesis."],"pmcid":["PMC11536148"],"funding_grant_id":["No.22206164","No.22276117","No.22036005","No. 202204051002024"],"pubmed_authors":["Li G","Li Z","Qin L","Ma L","Guo Y","Li D","He J","Sang N","YiXi Z","Gong Z","Yue H","Yan W"],"additional_accession":[]},"is_claimable":false,"name":"Maternal NO&lt;sub&gt;2&lt;/sub&gt; exposure and fetal growth restriction: Hypoxia transmission and lncRNAs-proinflammation-mediated abnormal hematopoiesis.","description":"Epidemiological studies show a strong correlation between air pollution and fetal growth restriction (FGR), but existing results are controversial due to inherent limitations, such as causality of specific pollutants, developmental origin, and maternal-fetal transmission. To address this controversy, we first conducted a retrospective analysis of 28,796 newborns and revealed that maternal nitrogen dioxide (NO<sub>2</sub>) exposure during the second trimester was positively associated with FGR, with an adjusted odds ratio of 1.075 (95% confidence interval: 1.020-1.133) per 10 μg/m<sup>3</sup> NO<sub>2</sub> increase for small for gestational age. Then, by establishing an animal model of prenatal NO<sub>2</sub> exposure, we confirmed its adverse effects on embryonic growth and hematopoiesis ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-01T05:19:11.855Z","creation":"2026-04-08T09:25:33.971Z"},"accession":"S-EPMC11536148","cross_references":{"pubmed":["39432779"],"doi":["10.1073/pnas.2409597121"]}}