biostudies-literatureQin LMOST | National Natural Science Foundation of China (NSFC)Special Fund for Scientific and Technological Innovation Talent Teams of Shanxi ProvinceMOST | National Natural Science Foundation of Chinae2409597121https://www.ebi.ac.uk/biostudies/studies/S-EPMC11536148biostudies-literatureUnknown121(44)Epidemiological studies show a strong correlation between air pollution and fetal growth restriction (FGR), but existing results are controversial due to inherent limitations, such as causality of specific pollutants, developmental origin, and maternal-fetal transmission. To address this controversy, we first conducted a retrospective analysis of 28,796 newborns and revealed that maternal nitrogen dioxide (NO₂) exposure during the second trimester was positively associated with FGR, with an adjusted odds ratio of 1.075 (95% confidence interval: 1.020-1.133) per 10 μg/m³ NO₂ increase for small for gestational age. Then, by establishing an animal model of prenatal NO₂ exposure, we confirmed its adverse effects on embryonic growth and hematopoiesis Proceedings of the National Academy of Sciences of the United States of AmericaMaternal NO<sub>2</sub> exposure and fetal growth restriction: Hypoxia transmission and lncRNAs-proinflammation-mediated abnormal hematopoiesis.PMC11536148No.22206164No.22276117No.22036005No. 202204051002024Li GLi ZQin LMa LGuo YLi DHe JSang NYiXi ZGong ZYue HYan WfalseMaternal NO<sub>2</sub> exposure and fetal growth restriction: Hypoxia transmission and lncRNAs-proinflammation-mediated abnormal hematopoiesis.Epidemiological studies show a strong correlation between air pollution and fetal growth restriction (FGR), but existing results are controversial due to inherent limitations, such as causality of specific pollutants, developmental origin, and maternal-fetal transmission. To address this controversy, we first conducted a retrospective analysis of 28,796 newborns and revealed that maternal nitrogen dioxide (NO₂) exposure during the second trimester was positively associated with FGR, with an adjusted odds ratio of 1.075 (95% confidence interval: 1.020-1.133) per 10 μg/m³ NO₂ increase for small for gestational age. Then, by establishing an animal model of prenatal NO₂ exposure, we confirmed its adverse effects on embryonic growth and hematopoiesis 2024-01-01T00:00:00Z2024 Oct2026-06-01T05:19:11.855Z2026-04-08T09:25:33.971ZS-EPMC115361483943277910.1073/pnas.2409597121