{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Z"],"funding":["Guangzhou Major Clinical Technology Project","Guangzhou Municipal Science and Technology Plan Project","Guangdong Key Laboratory of Plant Adaptation and Molecular Design","National Natural Science Foundation of China"],"pagination":["2420612"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11536693"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Probiotics serve as a novel preventive or therapeutic approach for dental caries owing to their ability to reverse dysbiosis and restore a healthy microbiota. Here, we identified <i>Burkholderia ambifaria</i> AFS098024 as a probiotic candidate isolated from plants.<h4>Methods</h4>The safety of <i>B. ambifaria</i> was evaluated by hemolytic activity, D-lactic acid production and antibiotic susceptibility. <i>In vitro</i> biofilm model derived from the saliva of caries-free and caries-active donors and <i>in vivo</i> rat caries model were used to assess the efficacy of <i>B. ambifaria</i> in caries prevention and treatment.<h4>Results</h4><i>B. ambifaria</i> was safe as a probiotic candidate and it could integrate with <i>in vitro</i> biofilm model. It significantly reduce"],"journal":["Journal of oral microbiology"],"pubmed_title":["Evaluation of a <i>Burkholderia ambifaria</i> strain from plants as a novel promising probiotic in dental caries management."],"pmcid":["PMC11536693"],"funding_grant_id":["No. 202201011112","No. 2023P-ZD07","No. 82201041","No. 2022B1212010013-6"],"pubmed_authors":["Wu L","Chen Z","Lu Y","Cai Y","Wei X","Xu Z"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of a <i>Burkholderia ambifaria</i> strain from plants as a novel promising probiotic in dental caries management.","description":"<h4>Background</h4>Probiotics serve as a novel preventive or therapeutic approach for dental caries owing to their ability to reverse dysbiosis and restore a healthy microbiota. Here, we identified <i>Burkholderia ambifaria</i> AFS098024 as a probiotic candidate isolated from plants.<h4>Methods</h4>The safety of <i>B. ambifaria</i> was evaluated by hemolytic activity, D-lactic acid production and antibiotic susceptibility. <i>In vitro</i> biofilm model derived from the saliva of caries-free and caries-active donors and <i>in vivo</i> rat caries model were used to assess the efficacy of <i>B. ambifaria</i> in caries prevention and treatment.<h4>Results</h4><i>B. ambifaria</i> was safe as a probiotic candidate and it could integrate with <i>in vitro</i> biofilm model. It significantly reduce","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-16T13:16:54.074Z","creation":"2025-04-04T18:54:01.629Z"},"accession":"S-EPMC11536693","cross_references":{"pubmed":["39502190"],"doi":["10.1080/20002297.2024.2420612"]}}