biostudies-literatureUnknown19(11)Ng Y<h4>Aims</h4>To compare the likelihood of being prescribed an antidepressant in depressed individuals with and without type 2 diabetes.<h4>Methods</h4>We performed a matched cohort study using primary care record data from the UK Clinical Practice Research Datalink. We used multivariable logistic regression to compare antidepressant prescribing during the first five years of starting oral antidiabetic medication to a comparison group without type 2 diabetes, matched based on GP practice, age and sex. We performed subgroup analyses stratified by sex, age and ethnicity.<h4>Results</h4>People with type 2 diabetes and depression were 75% less likely to be prescribed an antidepressant compared to people with depression alone (odds ratio (OR) 0.25, 95% confidence interval (CI) 0.25 to 0.26). ThiPloS onee0309153https://www.ebi.ac.uk/biostudies/studies/S-EPMC11537397biostudies-literatureAntidepressant prescribing inequalities in people with comorbid depression and type 2 diabetes: A UK primary care electronic health record study.PMC11537397Hayes JFNg YJeffery AfalseAntidepressant prescribing inequalities in people with comorbid depression and type 2 diabetes: A UK primary care electronic health record study.<h4>Aims</h4>To compare the likelihood of being prescribed an antidepressant in depressed individuals with and without type 2 diabetes.<h4>Methods</h4>We performed a matched cohort study using primary care record data from the UK Clinical Practice Research Datalink. We used multivariable logistic regression to compare antidepressant prescribing during the first five years of starting oral antidiabetic medication to a comparison group without type 2 diabetes, matched based on GP practice, age and sex. We performed subgroup analyses stratified by sex, age and ethnicity.<h4>Results</h4>People with type 2 diabetes and depression were 75% less likely to be prescribed an antidepressant compared to people with depression alone (odds ratio (OR) 0.25, 95% confidence interval (CI) 0.25 to 0.26). Thi2024-01-01T00:00:00Z20242025-04-04T18:54:01.341Z2025-04-04T18:54:01.341ZS-EPMC115373973949971310.1371/journal.pone.0309153