{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen R"],"funding":["Fundamental Research Funds for the Central Universities","National Key R&amp;D Program of China","Research Project of Jinan Microecological Biomedicine Shandong Laboratory","Shandong Provincial Laboratory Project","CAMS Innovation Fund for Medical Sciences","National Natural Science Foundation of China","Henan Provincial Science and Technology Research Project"],"pagination":["26817"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11538481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The increasing prevalence of carbapenem-resistant Enterobacter cloacae complex (CREC) poses great challenges to infection treatment in the clinical setting. In this study, we reported the emergence of carbapenemase in a rare species, Enterobacter chuandaensis, belonging to the Enterobacter cloacae complex (ECC). We elucidated the genetic characteristics of carbapenem-resistant isolate FAHZZU5885, co-harboring bla<sub>NDM-1</sub> and bla<sub>KPC-2</sub>. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and average nucleotide identity (ANI) analysis were used to identify E. chuandaensis. S1 nuclease pulsed-field gel electrophoresis (S1-PFGE) and Southern blotting were used to clarify the number and size of the plasmids in FAHZZU5885. Antimicrobial p"],"journal":["Scientific reports"],"pubmed_title":["First documentation of a clinical multidrug-resistant Enterobacter chuandaensis ST2493 isolate co-harboring bla<sub>NDM-1</sub> and two bla<sub>KPC-2</sub> bearing plasmids."],"pmcid":["PMC11538481"],"funding_grant_id":["2020YFE0204300","SYS202202","232102310176","82072314","JNL-2022011B","2019-I2M-5-045","2022ZFJH003"],"pubmed_authors":["Liu X","Liu Y","Li C","Guo X","Ge H","Liu R","Xu H","Shen Y","Chen R","Qiao J","Fang L"],"additional_accession":[]},"is_claimable":false,"name":"First documentation of a clinical multidrug-resistant Enterobacter chuandaensis ST2493 isolate co-harboring bla<sub>NDM-1</sub> and two bla<sub>KPC-2</sub> bearing plasmids.","description":"The increasing prevalence of carbapenem-resistant Enterobacter cloacae complex (CREC) poses great challenges to infection treatment in the clinical setting. In this study, we reported the emergence of carbapenemase in a rare species, Enterobacter chuandaensis, belonging to the Enterobacter cloacae complex (ECC). We elucidated the genetic characteristics of carbapenem-resistant isolate FAHZZU5885, co-harboring bla<sub>NDM-1</sub> and bla<sub>KPC-2</sub>. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and average nucleotide identity (ANI) analysis were used to identify E. chuandaensis. S1 nuclease pulsed-field gel electrophoresis (S1-PFGE) and Southern blotting were used to clarify the number and size of the plasmids in FAHZZU5885. Antimicrobial p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-01T17:41:32.825Z","creation":"2025-04-06T18:26:55.542Z"},"accession":"S-EPMC11538481","cross_references":{"pubmed":["39500966"],"doi":["10.1038/s41598-024-78163-2"]}}