biostudies-literatureHao YFundamental Research Funds for the Central UniversitiesNational Key R&D Program of Chinathe Lanzhou Youth Science and Technology Talent Innovation ProjectNational Natural Science Foundation of ChinaNational Key Research and Development Program of Chinae2406535https://www.ebi.ac.uk/biostudies/studies/S-EPMC11538673biostudies-literatureUnknown11(41)The extraction of lithium (Li) from complex brines presents significant challenges due to the interference of competing ions, particularly magnesium (Mg²⁺), which complicates the selective separation process. Herein, a strategy is introduced employing charge-lock enhanced 2D heterogeneous channels for the rapid and selective uptake of Li⁺. This approach integrates porous ZnFe₂O₄/ZnO nanosheets into Ag⁺-modulated sub-nanometer interlayer channels, forming channels optimized for Li⁺ extraction. The novelty lies in the charge-lock mechanism, which selectively captures Mg²⁺ ions, thereby facilitating the effective separation of Li from Mg. This mechanism is driven by a charge transfer during the formation of ZnFe₂O₄/ZAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Fine-Tuning 2D Heterogeneous Channels for Charge-Lock Enhanced Lithium Separation from Brine.PMC115386732023YFB3506902lzujbky-2021-sp3412105130lzujbky‐2023‐stlt01lzujbky-2023-stlt01lzujbky‐2021‐sp342023-QN-8832101149Liu XLi ZZhang YZhang XHao YChen XfalseFine-Tuning 2D Heterogeneous Channels for Charge-Lock Enhanced Lithium Separation from Brine.The extraction of lithium (Li) from complex brines presents significant challenges due to the interference of competing ions, particularly magnesium (Mg²⁺), which complicates the selective separation process. Herein, a strategy is introduced employing charge-lock enhanced 2D heterogeneous channels for the rapid and selective uptake of Li⁺. This approach integrates porous ZnFe₂O₄/ZnO nanosheets into Ag⁺-modulated sub-nanometer interlayer channels, forming channels optimized for Li⁺ extraction. The novelty lies in the charge-lock mechanism, which selectively captures Mg²⁺ ions, thereby facilitating the effective separation of Li from Mg. This mechanism is driven by a charge transfer during the formation of ZnFe₂O₄/Z2024-01-01T00:00:00Z2024 Nov2025-04-04T18:54:43.872Z2025-04-04T18:54:43.872ZS-EPMC115386733923494710.1002/advs.202406535