biostudies-literatureZhao LBasic and Applied Basic Research Foundation of Guangdong ProvinceNational Natural Science Foundation of Chinae39408https://www.ebi.ac.uk/biostudies/studies/S-EPMC11538951biostudies-literatureUnknown10(20)<h4>Objective</h4>The study aims to present an observational study of clinical trials on Oral Potentially Malignant Disorders (OPMDs) and corresponding publications.<h4>Study design and setting</h4>We searched the OPMDs-related clinical studies registered in the ClinicalTrials.gov database before March 1, 2024. Subsequently, we investigated the publication status of primary completed studies using PubMed and Google Scholar.<h4>Results</h4>A total of 185 studies were identified for analysis, including 141 interventional studies and 44 observational studies. The most commonly studied disease type was oral lichen planus (OLP), accounting for 113 studies (61.1 %). Interventional studies on OPMDs were predominantly early-phased, blind, randomized, parallel and single-center. The primary purposeHeliyonComprehensive analysis of clinical research profiles and study characteristics of oral potentially malignant disorders: an observational study.PMC115389512023107652022A15150107712024053182101017Zou ZZhao LFang JZhang YLu JQu YLi BWang ZfalseComprehensive analysis of clinical research profiles and study characteristics of oral potentially malignant disorders: an observational study.<h4>Objective</h4>The study aims to present an observational study of clinical trials on Oral Potentially Malignant Disorders (OPMDs) and corresponding publications.<h4>Study design and setting</h4>We searched the OPMDs-related clinical studies registered in the ClinicalTrials.gov database before March 1, 2024. Subsequently, we investigated the publication status of primary completed studies using PubMed and Google Scholar.<h4>Results</h4>A total of 185 studies were identified for analysis, including 141 interventional studies and 44 observational studies. The most commonly studied disease type was oral lichen planus (OLP), accounting for 113 studies (61.1 %). Interventional studies on OPMDs were predominantly early-phased, blind, randomized, parallel and single-center. The primary purpose2024-01-01T00:00:00Z2024 Oct2025-04-21T22:32:18.561Z2025-04-05T18:48:33.281ZS-EPMC115389513950695010.1016/j.heliyon.2024.e39408