{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["332(17)"],"submitter":["Perez-Fernandez X"],"pubmed_abstract":["<h4>Importance</h4>Cardiac surgery-associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulmonary bypass (CPB). Various strategies are proposed to attenuate CSA-AKI, including extracorporeal blood purification (EBP), but little is known about the effect of EBP through an acrylonitrile-sodium methallylsulfonate/polyethyleneimine membrane during CPB.<h4>Objective</h4>To determine whether the use of an EBP device in a nonemergent cardiac surgery population reduces CSA-AKI after CPB.<h4>Design, setting, and participants</h4>This double-blind, randomized clinical trial was conducted in 2 tertiary hospitals in Spain. Patients 18 years or older undergoing nonemergent cardiac surgery who were at high risk for CSA-AKI were enrolled from June 15, 2016, through Novem"],"journal":["JAMA"],"pagination":["1446-1454"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539008"],"repository":["biostudies-literature"],"pubmed_title":["Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial."],"pmcid":["PMC11539008"],"pubmed_authors":["Gutierrez Y","Rodenas Gomez F","Garcia-Morron Gallego A","Plata-Menchaca E","Gimenez Vila V","Ordonez Llanos J","Vazquez Guillamet B","Berastegui Garcia E","Rodriguez Nunez M","Ojeda Jimenez V","Rigo Bonnin R","Gumucio-Sanguino V","Olivera Rodriguez T","Martinez Ocon S","Burgos Naranjo MA","SIRAKI02 Study Group","Penafiel-Munoz J","Campoy A","Llamas Bolta M","Perez Soria D","Dantas A","Mendoza Jimenez C","Claveria O","Delgado Ramis L","Farrero Bayarri E","Potocnik Potocnik M","Martinez Sepena L","Ausio Navarro M","Cabana Benjumea A","Moreno Duran A","Garces Gimeno B","Belda Ley MD","Serrano Jaureguizar S","Coluccio Pereira EE","Mancino Contreras JM","Garcia Ballester S","Sanchez Escudero M","Farre Estebe A","Hueso M","Velazquez Torres M","Llamas Ruiz J","Mendez Arias E","Hamed Loukili S","Puente Mora E","Sastre Perez P","Castillo J","Farigola Munuera ME","Benveniste Perez E","Bonet Cruces E","Granada Vicente R","Leon Moreno A","Gonzalez Romero M","Torrado Santos HR","Sbraga F","Tomasa Irriguible T","Sabater-Riera J","Piquer Robles C","Boronat-Garcia P","Pons Serra M","Carretero Aguila J","Buendia Flores R","Martinez Orellana M","Lopez Delgado JC","Maisterra Santos K","Carrio Cardona ML","Gonzalez Pujol A","Torreguitart I","Buys S","Perez-Fernandez X","Hernandez Platero L","Santiago-Bautista D","Bauca Socies M","Santafosta Gomez E","Barranco Rodriguez A","Camara-Rosell M","Perea Sanchez L","Sanchez Satorra M","Valls Estrada EA","Modrego Montiel E","Betbese-Roig A","Ruiz Artola V","Serra Paya P","Rodriguez Gonzalez D","Martinez Vega S","Cevallos B","Miralles Cassina A","Gracia Martinez A","Mora V","Tora Navarro L","Montero N","Ochagavia Calvo AR","Costa Capela L","Bervel Franco D","Bielsa Berrocal L","Oliver Juan E","Charlotte Philibert VJ","Rodriguez Contreras P","Gonzalez Lopez C","Alanez Saavedra BH","Mota Montane DP","Iglesias Gordillo F","Estruch M","Avila Espinoza RS","Torres Aparicio O","Cabezas Garrido S","Camacho-Perez M","Del Rio Sanchez A","Gascon Tomas L","Fernandez Gallego C","Finestres Martin M","Ibern Navarro L","Montoya Perez A","Munoz Del Rio G","Fabra Radua M","Moreno GJ","Ayala Gallardo M","Rodriguez Fanjul J","Rodriguez Pedreira P","Manez Mendiluce R","Castano Camunez J","Duran Colacios M","Ramos Puig JM","Osorio Higa K","CarrionSanchez A","Cardenas Campos P","Sanz Iturbe M","Periche Pedra E","Di Paolo FA","Bonet Burguera A","Nogales Ibanez R","Rodriguez Castro D","Julia Valls C","Arnaiz Francos A","Blasco Lucas A","Puig Aragon A","Ortiz Berbel D","Corral VF","Prieto Palomino S","Marti Massanas L","Via Clavero G","Roig Pineda R","Anguela Calvet L","Gonzalez Barrera L","Pons Lopez T","Peribanez Biedma C","Anglada Olivan M","Gil Ginebra C","Masso Lago E","Sarinena Fernandez MT","Escudero Teixido A","Mesa Carrizosa C","Querol Parra","Briones Roc M","Lopez Sune N","Ruiz de Pablo B","Alonso Juste V","Forni L","Ulsamer A","Sanjuan Navais M","Mora Muniz V","Cardenete Villarroyo A","Perez Gonzalez V","Boza Hernandez E","Hurtado Hidalgo S","Figuereo Beltre D","Blasco Torres C","Oliveras M","Esteve Urbano F","Herrera RS","Justel Garcia RF","Vera Martinez A","Pujadas Fernandez-Cordeiro M","Moret-Ruiz E","Garcia Zalona A","Casanovas Lorenzo T","Bautista Correa MJ","Catalan Eraso B","Toscano Fernandez J","Boza-Hernandez E","Fuentes Mila V","Lerma Brianso C","Toral Sepulveda D","Diago Ferre M","Corral Ansa L","Gonzalez Martinez E","Gonzalez Del Hoyo S","Ballus Noguera J","Sanz Mellado C","Albendea Perell C","Perez Sanchez J","Romera Peregrina I","Romero Ferrer B","Tejero J","Chavez Diandreras F","Soley Corderas R","Chinchilla Perez A","Cruz Bardina S","Gil Dorado A","Julia Amill I","Campos-Gomez A","Badia Gamarra S","Huguet Briba M","Fuset Cabanes MP","Lopez Gonzalez O","Raguer Pardo L","Moreno Duran AM","Moreno Santoro A","Bruguera E","Lores AC","Luna Solis SM"],"additional_accession":[]},"is_claimable":false,"name":"Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial.","description":"<h4>Importance</h4>Cardiac surgery-associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulmonary bypass (CPB). Various strategies are proposed to attenuate CSA-AKI, including extracorporeal blood purification (EBP), but little is known about the effect of EBP through an acrylonitrile-sodium methallylsulfonate/polyethyleneimine membrane during CPB.<h4>Objective</h4>To determine whether the use of an EBP device in a nonemergent cardiac surgery population reduces CSA-AKI after CPB.<h4>Design, setting, and participants</h4>This double-blind, randomized clinical trial was conducted in 2 tertiary hospitals in Spain. Patients 18 years or older undergoing nonemergent cardiac surgery who were at high risk for CSA-AKI were enrolled from June 15, 2016, through Novem","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-01T10:42:48.864Z","creation":"2025-07-13T03:05:09.448Z"},"accession":"S-EPMC11539008","cross_references":{"pubmed":["39382234"],"doi":["10.1001/jama.2024.20630"]}}