biostudies-literatureUnknown332(17)Perez-Fernandez X<h4>Importance</h4>Cardiac surgery-associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulmonary bypass (CPB). Various strategies are proposed to attenuate CSA-AKI, including extracorporeal blood purification (EBP), but little is known about the effect of EBP through an acrylonitrile-sodium methallylsulfonate/polyethyleneimine membrane during CPB.<h4>Objective</h4>To determine whether the use of an EBP device in a nonemergent cardiac surgery population reduces CSA-AKI after CPB.<h4>Design, setting, and participants</h4>This double-blind, randomized clinical trial was conducted in 2 tertiary hospitals in Spain. Patients 18 years or older undergoing nonemergent cardiac surgery who were at high risk for CSA-AKI were enrolled from June 15, 2016, through NovemJAMA1446-1454https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539008biostudies-literatureExtracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial.PMC11539008Gutierrez YRodenas Gomez FGarcia-Morron Gallego APlata-Menchaca EGimenez Vila VOrdonez Llanos JVazquez Guillamet BBerastegui Garcia ERodriguez Nunez MOjeda Jimenez VRigo Bonnin RGumucio-Sanguino VOlivera Rodriguez TMartinez Ocon SBurgos Naranjo MASIRAKI02 Study GroupPenafiel-Munoz JCampoy ALlamas Bolta MPerez Soria DDantas AMendoza Jimenez CClaveria ODelgado Ramis LFarrero Bayarri EPotocnik Potocnik MMartinez Sepena LAusio Navarro MCabana Benjumea AMoreno Duran AGarces Gimeno BBelda Ley MDSerrano Jaureguizar SColuccio Pereira EEMancino Contreras JMGarcia Ballester SSanchez Escudero MFarre Estebe AHueso MVelazquez Torres MLlamas Ruiz JMendez Arias EHamed Loukili SPuente Mora ESastre Perez PCastillo JFarigola Munuera MEBenveniste Perez EBonet Cruces EGranada Vicente RLeon Moreno AGonzalez Romero MTorrado Santos HRSbraga FTomasa Irriguible TSabater-Riera JPiquer Robles CBoronat-Garcia PPons Serra MCarretero Aguila JBuendia Flores RMartinez Orellana MLopez Delgado JCMaisterra Santos KCarrio Cardona MLGonzalez Pujol ATorreguitart IBuys SPerez-Fernandez XHernandez Platero LSantiago-Bautista DBauca Socies MSantafosta Gomez EBarranco Rodriguez ACamara-Rosell MPerea Sanchez LSanchez Satorra MValls Estrada EAModrego Montiel EBetbese-Roig ARuiz Artola VSerra Paya PRodriguez Gonzalez DMartinez Vega SCevallos BMiralles Cassina AGracia Martinez AMora VTora Navarro LMontero NOchagavia Calvo ARCosta Capela LBervel Franco DBielsa Berrocal LOliver Juan ECharlotte Philibert VJRodriguez Contreras PGonzalez Lopez CAlanez Saavedra BHMota Montane DPIglesias Gordillo FEstruch MAvila Espinoza RSTorres Aparicio OCabezas Garrido SCamacho-Perez MDel Rio Sanchez AGascon Tomas LFernandez Gallego CFinestres Martin MIbern Navarro LMontoya Perez AMunoz Del Rio GFabra Radua MMoreno GJAyala Gallardo MRodriguez Fanjul JRodriguez Pedreira PManez Mendiluce RCastano Camunez JDuran Colacios MRamos Puig JMOsorio Higa KCarrionSanchez ACardenas Campos PSanz Iturbe MPeriche Pedra EDi Paolo FABonet Burguera ANogales Ibanez RRodriguez Castro DJulia Valls CArnaiz Francos ABlasco Lucas APuig Aragon AOrtiz Berbel DCorral VFPrieto Palomino SMarti Massanas LVia Clavero GRoig Pineda RAnguela Calvet LGonzalez Barrera LPons Lopez TPeribanez Biedma CAnglada Olivan MGil Ginebra CMasso Lago ESarinena Fernandez MTEscudero Teixido AMesa Carrizosa CQuerol ParraBriones Roc MLopez Sune NRuiz de Pablo BAlonso Juste VForni LUlsamer ASanjuan Navais MMora Muniz VCardenete Villarroyo APerez Gonzalez VBoza Hernandez EHurtado Hidalgo SFiguereo Beltre DBlasco Torres COliveras MEsteve Urbano FHerrera RSJustel Garcia RFVera Martinez APujadas Fernandez-Cordeiro MMoret-Ruiz EGarcia Zalona ACasanovas Lorenzo TBautista Correa MJCatalan Eraso BToscano Fernandez JBoza-Hernandez EFuentes Mila VLerma Brianso CToral Sepulveda DDiago Ferre MCorral Ansa LGonzalez Martinez EGonzalez Del Hoyo SBallus Noguera JSanz Mellado CAlbendea Perell CPerez Sanchez JRomera Peregrina IRomero Ferrer BTejero JChavez Diandreras FSoley Corderas RChinchilla Perez ACruz Bardina SGil Dorado AJulia Amill ICampos-Gomez ABadia Gamarra SHuguet Briba MFuset Cabanes MPLopez Gonzalez ORaguer Pardo LMoreno Duran AMMoreno Santoro ABruguera ELores ACLuna Solis SMfalseExtracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial.<h4>Importance</h4>Cardiac surgery-associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulmonary bypass (CPB). Various strategies are proposed to attenuate CSA-AKI, including extracorporeal blood purification (EBP), but little is known about the effect of EBP through an acrylonitrile-sodium methallylsulfonate/polyethyleneimine membrane during CPB.<h4>Objective</h4>To determine whether the use of an EBP device in a nonemergent cardiac surgery population reduces CSA-AKI after CPB.<h4>Design, setting, and participants</h4>This double-blind, randomized clinical trial was conducted in 2 tertiary hospitals in Spain. Patients 18 years or older undergoing nonemergent cardiac surgery who were at high risk for CSA-AKI were enrolled from June 15, 2016, through Novem2024-01-01T00:00:00Z2024 Nov2026-06-01T10:42:48.864Z2025-07-13T03:05:09.448ZS-EPMC115390083938223410.1001/jama.2024.20630