{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["44"],"submitter":["Huang J"],"pubmed_abstract":["The significance of collagen and vascular in skin augmentation have been recognized in recent years. However, current skin tissue fillers, <i>e.g.</i> hyaluronic acid (HA) or HA-based hydrogel, fail to meet the perfect augmentation requirements due to their inadequate long-term support effect and the lack of tissue-inducing activity. Herein, an injectable skin filler containing hyaluronic acid (HA) hydrogel and lithium calcium silicate (LCS, Li<sub>2</sub>Ca<sub>4</sub>Si<sub>4</sub>O<sub>13</sub>) bioceramic microspheres was developed for skin tissue fillers, owing to the excellent biological function of silicate bioceramics. The HA-LCS fillers could be easily injected through a tiny standard medical needle (27 G) with force of less than 36 N, and showed good biocompatibility both <i>in v"],"journal":["Bioactive materials"],"pagination":["256-268"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539074"],"repository":["biostudies-literature"],"pubmed_title":["An injectable hyaluronic acid/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration."],"pmcid":["PMC11539074"],"pubmed_authors":["Zhai D","Huang J","Zhu Y","Zhang X","Zhang H","Wu C","Xue J","Du L","Huan Z"],"additional_accession":[]},"is_claimable":false,"name":"An injectable hyaluronic acid/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration.","description":"The significance of collagen and vascular in skin augmentation have been recognized in recent years. However, current skin tissue fillers, <i>e.g.</i> hyaluronic acid (HA) or HA-based hydrogel, fail to meet the perfect augmentation requirements due to their inadequate long-term support effect and the lack of tissue-inducing activity. Herein, an injectable skin filler containing hyaluronic acid (HA) hydrogel and lithium calcium silicate (LCS, Li<sub>2</sub>Ca<sub>4</sub>Si<sub>4</sub>O<sub>13</sub>) bioceramic microspheres was developed for skin tissue fillers, owing to the excellent biological function of silicate bioceramics. The HA-LCS fillers could be easily injected through a tiny standard medical needle (27 G) with force of less than 36 N, and showed good biocompatibility both <i>in v","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T09:36:46.278Z","creation":"2025-04-04T09:36:46.278Z"},"accession":"S-EPMC11539074","cross_references":{"pubmed":["39507373"],"doi":["10.1016/j.bioactmat.2024.10.014"]}}