biostudies-literatureUnknown44Huang JThe significance of collagen and vascular in skin augmentation have been recognized in recent years. However, current skin tissue fillers, <i>e.g.</i> hyaluronic acid (HA) or HA-based hydrogel, fail to meet the perfect augmentation requirements due to their inadequate long-term support effect and the lack of tissue-inducing activity. Herein, an injectable skin filler containing hyaluronic acid (HA) hydrogel and lithium calcium silicate (LCS, Li₂Ca₄Si₄O₁₃) bioceramic microspheres was developed for skin tissue fillers, owing to the excellent biological function of silicate bioceramics. The HA-LCS fillers could be easily injected through a tiny standard medical needle (27 G) with force of less than 36 N, and showed good biocompatibility both <i>in vBioactive materials256-268https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539074biostudies-literatureAn injectable hyaluronic acid/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration.PMC11539074Zhai DHuang JZhu YZhang XZhang HWu CXue JDu LHuan ZfalseAn injectable hyaluronic acid/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration.The significance of collagen and vascular in skin augmentation have been recognized in recent years. However, current skin tissue fillers, <i>e.g.</i> hyaluronic acid (HA) or HA-based hydrogel, fail to meet the perfect augmentation requirements due to their inadequate long-term support effect and the lack of tissue-inducing activity. Herein, an injectable skin filler containing hyaluronic acid (HA) hydrogel and lithium calcium silicate (LCS, Li₂Ca₄Si₄O₁₃) bioceramic microspheres was developed for skin tissue fillers, owing to the excellent biological function of silicate bioceramics. The HA-LCS fillers could be easily injected through a tiny standard medical needle (27 G) with force of less than 36 N, and showed good biocompatibility both <i>in v2025-01-01T00:00:00Z2025 Feb2025-04-04T09:36:46.278Z2025-04-04T09:36:46.278ZS-EPMC115390743950737310.1016/j.bioactmat.2024.10.014