{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Y"],"funding":["National Natural Science Foundation of China","Key Research and Development Program of Sichuan Province","National Engineering Research Center of Solid-State Brewing"],"pagination":["154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539552"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Fatigue is a prevalent issue that can lead individuals to a sub-health condition, impacting their work efficiency and quality of life. There are limited effective treatment options available for fatigue. Ren-Shen-Bu-Qi decoction (RSBQD) is a proprietary herbal remedy that is designed to address fatigue. However, the specific pharmacological mechanisms and basis of RSBQD are not yet fully understood.<h4>Purpose</h4>This study aimed to investigate the pharmacological effects and mechanisms of RSBQD in a mouse model of exercise fatigue.<h4>Materials and methods</h4>UPLC-Q-Orbitrap HRMS was used to analyze the chemical composition of RSBQD. The pharmacological basis and molecular mechanism of RSBQD on exercise fatigue were predicted using network pharmacology analysis. Subse"],"journal":["Chinese medicine"],"pubmed_title":["Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice."],"pmcid":["PMC11539552"],"funding_grant_id":["30801522","82373998","2023YFD1600401","NJGS-2023000407"],"pubmed_authors":["Shen C","Liu S","Zhou Y","Zhang W","Liu X","Guo J","Zhao R","Huang Z","Wang S","Chen Y","Bai J","Gao T","Deng Y"],"additional_accession":[]},"is_claimable":false,"name":"Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice.","description":"<h4>Background</h4>Fatigue is a prevalent issue that can lead individuals to a sub-health condition, impacting their work efficiency and quality of life. There are limited effective treatment options available for fatigue. Ren-Shen-Bu-Qi decoction (RSBQD) is a proprietary herbal remedy that is designed to address fatigue. However, the specific pharmacological mechanisms and basis of RSBQD are not yet fully understood.<h4>Purpose</h4>This study aimed to investigate the pharmacological effects and mechanisms of RSBQD in a mouse model of exercise fatigue.<h4>Materials and methods</h4>UPLC-Q-Orbitrap HRMS was used to analyze the chemical composition of RSBQD. The pharmacological basis and molecular mechanism of RSBQD on exercise fatigue were predicted using network pharmacology analysis. Subse","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-07-11T03:03:59.875Z","creation":"2025-04-05T18:48:34.645Z"},"accession":"S-EPMC11539552","cross_references":{"pubmed":["39501343"],"doi":["10.1186/s13020-024-01027-4"]}}