biostudies-literatureChen YNational Natural Science Foundation of ChinaKey Research and Development Program of Sichuan ProvinceNational Engineering Research Center of Solid-State Brewing154https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539552biostudies-literatureUnknown19(1)<h4>Background</h4>Fatigue is a prevalent issue that can lead individuals to a sub-health condition, impacting their work efficiency and quality of life. There are limited effective treatment options available for fatigue. Ren-Shen-Bu-Qi decoction (RSBQD) is a proprietary herbal remedy that is designed to address fatigue. However, the specific pharmacological mechanisms and basis of RSBQD are not yet fully understood.<h4>Purpose</h4>This study aimed to investigate the pharmacological effects and mechanisms of RSBQD in a mouse model of exercise fatigue.<h4>Materials and methods</h4>UPLC-Q-Orbitrap HRMS was used to analyze the chemical composition of RSBQD. The pharmacological basis and molecular mechanism of RSBQD on exercise fatigue were predicted using network pharmacology analysis. SubseChinese medicineRen-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice.PMC1153955230801522823739982023YFD1600401NJGS-2023000407Shen CLiu SZhou YZhang WLiu XGuo JZhao RHuang ZWang SChen YBai JGao TDeng YfalseRen-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice.<h4>Background</h4>Fatigue is a prevalent issue that can lead individuals to a sub-health condition, impacting their work efficiency and quality of life. There are limited effective treatment options available for fatigue. Ren-Shen-Bu-Qi decoction (RSBQD) is a proprietary herbal remedy that is designed to address fatigue. However, the specific pharmacological mechanisms and basis of RSBQD are not yet fully understood.<h4>Purpose</h4>This study aimed to investigate the pharmacological effects and mechanisms of RSBQD in a mouse model of exercise fatigue.<h4>Materials and methods</h4>UPLC-Q-Orbitrap HRMS was used to analyze the chemical composition of RSBQD. The pharmacological basis and molecular mechanism of RSBQD on exercise fatigue were predicted using network pharmacology analysis. Subse2024-01-01T00:00:00Z2024 Nov2025-07-11T03:03:59.875Z2025-04-05T18:48:34.645ZS-EPMC115395523950134310.1186/s13020-024-01027-4