{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen X"],"funding":["Natural Science Foundation of Hunan Province","Basic and Applied Basic Research Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["248"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539619"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential in influencing tumor progression. Therefore, it is important to evaluate the clinical and functional role of SARS-CoV-2 on tumor progression.<h4>Methods</h4>Here, we integrated bioinformatic analysis of COVID-19 RNA-seq data from the GEO database and performed functional studies to explore the regulatory role of SARS-CoV-2 in solid tumor progression, including lung, colon, kidney and liver cancer.<h4>Results</h4>Our results demonstrate that infection with SARS-CoV-2 is associated with a decreased expression of genes associated with cancer proliferation and metastasis in lung "],"journal":["Molecular cancer"],"pubmed_title":["SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization."],"pmcid":["PMC11539619"],"funding_grant_id":["2021A1515011065","81730061","32200117","82072834","2023JJ60495"],"pubmed_authors":["Yang G","Wu J","Huang C","Gu Y","Luo Z","Deng M","Zhang Q","Liu Y","Wang N","Li Y","Lei Z","Zhang X","Pan P","Jiang B","Chen X","Zhou F","Yue Z"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization.","description":"<h4>Background</h4>SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential in influencing tumor progression. Therefore, it is important to evaluate the clinical and functional role of SARS-CoV-2 on tumor progression.<h4>Methods</h4>Here, we integrated bioinformatic analysis of COVID-19 RNA-seq data from the GEO database and performed functional studies to explore the regulatory role of SARS-CoV-2 in solid tumor progression, including lung, colon, kidney and liver cancer.<h4>Results</h4>Our results demonstrate that infection with SARS-CoV-2 is associated with a decreased expression of genes associated with cancer proliferation and metastasis in lung ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-15T08:08:15.808Z","creation":"2025-04-04T12:01:08.374Z"},"accession":"S-EPMC11539619","cross_references":{"pubmed":["39506849"],"doi":["10.1186/s12943-024-02153-1"]}}