biostudies-literatureChen XNatural Science Foundation of Hunan ProvinceBasic and Applied Basic Research Foundation of Guangdong ProvinceNational Natural Science Foundation of China248https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539619biostudies-literatureUnknown23(1)<h4>Background</h4>SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential in influencing tumor progression. Therefore, it is important to evaluate the clinical and functional role of SARS-CoV-2 on tumor progression.<h4>Methods</h4>Here, we integrated bioinformatic analysis of COVID-19 RNA-seq data from the GEO database and performed functional studies to explore the regulatory role of SARS-CoV-2 in solid tumor progression, including lung, colon, kidney and liver cancer.<h4>Results</h4>Our results demonstrate that infection with SARS-CoV-2 is associated with a decreased expression of genes associated with cancer proliferation and metastasis in lung Molecular cancerSARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization.PMC115396192021A15150110658173006132200117820728342023JJ60495Yang GWu JHuang CGu YLuo ZDeng MZhang QLiu YWang NLi YLei ZZhang XPan PJiang BChen XZhou FYue ZfalseSARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization.<h4>Background</h4>SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential in influencing tumor progression. Therefore, it is important to evaluate the clinical and functional role of SARS-CoV-2 on tumor progression.<h4>Methods</h4>Here, we integrated bioinformatic analysis of COVID-19 RNA-seq data from the GEO database and performed functional studies to explore the regulatory role of SARS-CoV-2 in solid tumor progression, including lung, colon, kidney and liver cancer.<h4>Results</h4>Our results demonstrate that infection with SARS-CoV-2 is associated with a decreased expression of genes associated with cancer proliferation and metastasis in lung 2024-01-01T00:00:00Z2024 Nov2026-07-15T08:08:15.808Z2025-04-04T12:01:08.374ZS-EPMC115396193950684910.1186/s12943-024-02153-1