{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu X"],"funding":["Shanghai Municipal Science and Technology Major Project","Strategic Priority CAS Project","the Startup grant at Fudan University","National Natural Science Foundation of China"],"pagination":["245"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539626"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Facial aging, cognitive impairment, and dementia are all age-related conditions. However, the temporal relation between facial age and future risk of dementia was not systematically examined.<h4>Objectives</h4>To investigate the relationship between facial age (both subjective/perceived and objective) and cognitive impairment and/or dementia risk.<h4>Methods</h4>The study included 195,329 participants (age ≥ 60 y) from the UK Biobank (UKB) with self-perceived facial age and 612 participants from the Nutrition and Health of Aging Population in China Project (NHAPC) study (age ≥ 56 y) with objective assessment of facial age. Cox proportional hazards model was used to prospectively examine the hazard ratios (HRs) and their 95% confidence intervals (CIs) of self-perceived fa"],"journal":["Alzheimer's research & therapy"],"pubmed_title":["Facial aging, cognitive impairment, and dementia risk."],"pmcid":["PMC11539626"],"funding_grant_id":["XDB38010300","2017SHZDZX01","JIF201036Y","81970684"],"pubmed_authors":["Gu X","Guo Y","Ma Y","Lin X","Gunn DA","Wang J","Sun L","Liu Y","Li Y","Jigeer G","Wang S","Chen X","Gao X","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"Facial aging, cognitive impairment, and dementia risk.","description":"<h4>Background</h4>Facial aging, cognitive impairment, and dementia are all age-related conditions. However, the temporal relation between facial age and future risk of dementia was not systematically examined.<h4>Objectives</h4>To investigate the relationship between facial age (both subjective/perceived and objective) and cognitive impairment and/or dementia risk.<h4>Methods</h4>The study included 195,329 participants (age ≥ 60 y) from the UK Biobank (UKB) with self-perceived facial age and 612 participants from the Nutrition and Health of Aging Population in China Project (NHAPC) study (age ≥ 56 y) with objective assessment of facial age. Cox proportional hazards model was used to prospectively examine the hazard ratios (HRs) and their 95% confidence intervals (CIs) of self-perceived fa","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-16T14:58:41.324Z","creation":"2025-04-04T14:57:06.472Z"},"accession":"S-EPMC11539626","cross_references":{"pubmed":["39506848"],"doi":["10.1186/s13195-024-01611-8"]}}