biostudies-literatureXu XShanghai Municipal Science and Technology Major ProjectStrategic Priority CAS Projectthe Startup grant at Fudan UniversityNational Natural Science Foundation of China245https://www.ebi.ac.uk/biostudies/studies/S-EPMC11539626biostudies-literatureUnknown16(1)<h4>Background</h4>Facial aging, cognitive impairment, and dementia are all age-related conditions. However, the temporal relation between facial age and future risk of dementia was not systematically examined.<h4>Objectives</h4>To investigate the relationship between facial age (both subjective/perceived and objective) and cognitive impairment and/or dementia risk.<h4>Methods</h4>The study included 195,329 participants (age ≥ 60 y) from the UK Biobank (UKB) with self-perceived facial age and 612 participants from the Nutrition and Health of Aging Population in China Project (NHAPC) study (age ≥ 56 y) with objective assessment of facial age. Cox proportional hazards model was used to prospectively examine the hazard ratios (HRs) and their 95% confidence intervals (CIs) of self-perceived faAlzheimer's research & therapyFacial aging, cognitive impairment, and dementia risk.PMC11539626XDB380103002017SHZDZX01JIF201036Y81970684Gu XGuo YMa YLin XGunn DAWang JSun LLiu YLi YJigeer GWang SChen XGao XXu XfalseFacial aging, cognitive impairment, and dementia risk.<h4>Background</h4>Facial aging, cognitive impairment, and dementia are all age-related conditions. However, the temporal relation between facial age and future risk of dementia was not systematically examined.<h4>Objectives</h4>To investigate the relationship between facial age (both subjective/perceived and objective) and cognitive impairment and/or dementia risk.<h4>Methods</h4>The study included 195,329 participants (age ≥ 60 y) from the UK Biobank (UKB) with self-perceived facial age and 612 participants from the Nutrition and Health of Aging Population in China Project (NHAPC) study (age ≥ 56 y) with objective assessment of facial age. Cox proportional hazards model was used to prospectively examine the hazard ratios (HRs) and their 95% confidence intervals (CIs) of self-perceived fa2024-01-01T00:00:00Z2024 Nov2026-07-16T14:58:41.324Z2025-04-04T14:57:06.472ZS-EPMC115396263950684810.1186/s13195-024-01611-8