{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Okamoto F"],"funding":["NIAMS","NIDA NIH HHS","NIAMS NIH HHS","NIDA"],"pagination":["jkae213"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11540319"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["Genome-wide association studies typically evaluate the autosomes and sometimes the X Chromosome, but seldom consider the Y or mitochondrial (MT) Chromosomes. We genotyped the Y and MT Chromosomes in heterogeneous stock (HS) rats (Rattus norvegicus), an outbred population created from 8 inbred strains. We identified 8 distinct Y and 4 distinct MT Chromosomes among the 8 founders. However, only 2 types of each nonrecombinant chromosome were observed in our modern HS rat population (generations 81-97). Despite the relatively large sample size, there were virtually no significant associations for behavioral, physiological, metabolome, or microbiome traits after correcting for multiple comparisons. However, both Y and MT Chromosomes were strongly associated with the expression of a few genes lo"],"journal":["G3 (Bethesda, Md.)"],"pubmed_title":["Y and mitochondrial chromosomes in the heterogeneous stock rat population."],"pmcid":["PMC11540319"],"funding_grant_id":["P50 DA037844","R01AR070879","R01 AR070879","P50DA037844"],"pubmed_authors":["Ishiwari K","George O","Han W","Carrette LLG","Jablonski MM","Beeson A","Adams DJ","Kallupi M","Wang T","Kuhn BN","de Guglielmo G","Jhou TC","Bimschleger HV","Peng BF","Solberg Woods LC","Meyer PJ","Baud A","Dorrestein P","Okamoto F","Johnson BB","Tripi JA","Garcia Martinez AG","Jackson T","Polesskaya O","Ziegler KS","King CP","Chen H","Munro D","Chen D","Aron AT","Eid M","Knight R","Missfeldt Sanches T","Netzley AH","Chitre AS","Palmer AA","Holl K","Lamparelli AC","Nguyen KH"],"additional_accession":[]},"is_claimable":false,"name":"Y and mitochondrial chromosomes in the heterogeneous stock rat population.","description":"Genome-wide association studies typically evaluate the autosomes and sometimes the X Chromosome, but seldom consider the Y or mitochondrial (MT) Chromosomes. We genotyped the Y and MT Chromosomes in heterogeneous stock (HS) rats (Rattus norvegicus), an outbred population created from 8 inbred strains. We identified 8 distinct Y and 4 distinct MT Chromosomes among the 8 founders. However, only 2 types of each nonrecombinant chromosome were observed in our modern HS rat population (generations 81-97). Despite the relatively large sample size, there were virtually no significant associations for behavioral, physiological, metabolome, or microbiome traits after correcting for multiple comparisons. However, both Y and MT Chromosomes were strongly associated with the expression of a few genes lo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-09T11:59:13.8Z","creation":"2025-04-22T09:41:21.767Z"},"accession":"S-EPMC11540319","cross_references":{"pubmed":["39250761"],"doi":["10.1093/g3journal/jkae213"]}}