biostudies-literatureUnknown15Jiang L<h4>Background</h4>Acute lung injury (ALI) is a serious and common complication that occurs in children with congenital heart disease after cardiopulmonary bypass (CPB) surgery, leading to higher mortality rates and poorer prognosis. Currently, there is no reliable predictive strategy for CPB-associated lung injury (CPB-ALI) in infants. Certain characteristics of the gut microbiota could potentially serve as biomarkers for predicting the development of CPB-ALI.<h4>Methods</h4>We conducted 16S rRNA sequencing to analyze the characteristics of the intestinal microbiota in healthy controls and infants with CHD admitted to the hospital. The CHD infants were divided into CPB-ALI and non-ALI (CPB-NALI) groups based on postoperative outcomes. Bacterial functional pathway prediction analysis was pFrontiers in immunology1362040https://www.ebi.ac.uk/biostudies/studies/S-EPMC11540645biostudies-literaturePredicting acute lung injury in infants with congenital heart disease after cardiopulmonary bypass by gut microbiota.PMC11540645Wu KWu ZYang ZPatel NJiang LCun YWang QQi JHu MZhu TCai XMo XfalsePredicting acute lung injury in infants with congenital heart disease after cardiopulmonary bypass by gut microbiota.<h4>Background</h4>Acute lung injury (ALI) is a serious and common complication that occurs in children with congenital heart disease after cardiopulmonary bypass (CPB) surgery, leading to higher mortality rates and poorer prognosis. Currently, there is no reliable predictive strategy for CPB-associated lung injury (CPB-ALI) in infants. Certain characteristics of the gut microbiota could potentially serve as biomarkers for predicting the development of CPB-ALI.<h4>Methods</h4>We conducted 16S rRNA sequencing to analyze the characteristics of the intestinal microbiota in healthy controls and infants with CHD admitted to the hospital. The CHD infants were divided into CPB-ALI and non-ALI (CPB-NALI) groups based on postoperative outcomes. Bacterial functional pathway prediction analysis was p2024-01-01T00:00:00Z20242026-07-09T13:19:22.783Z2025-04-06T11:47:27.001ZS-EPMC115406453951235410.3389/fimmu.2024.1362040