{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Yuan J"],"pubmed_abstract":["<h4>Background</h4>With an aging population, knee arthroplasty is increasingly common; however, chronic postsurgical pain (CPSP) affects up to 30% of patients. This study aims to evaluate the efficacy of 5% lidocaine-medicated plaster (LP5) in preventing CPSP among patients undergoing knee arthroplasty.<h4>Methods</h4>This is a dual-center, randomized, double-blind, placebo-controlled trial involving 128 adult patients scheduled for knee arthroplasty. Participants will be randomly assigned, stratified by center, to either the LP5 group or the placebo group (n = 64 per group). The LP5 or placebo group will apply the patch 1 day before surgery and on postoperative days 1-3, with multimodal analgesia administered postoperatively. Multimodal analgesia will include intraoperative flurbiprofen a"],"journal":["Frontiers in pharmacology"],"pagination":["1486217"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11540780"],"repository":["biostudies-literature"],"pubmed_title":["Effect of 5% lidocaine-medicated plaster in preventing chronic postsurgical pain after knee replacement: protocol for a randomized double-blind placebo-controlled trial."],"pmcid":["PMC11540780"],"pubmed_authors":["Li Y","Jin X","Guo J","Xu H","Yuan J","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Effect of 5% lidocaine-medicated plaster in preventing chronic postsurgical pain after knee replacement: protocol for a randomized double-blind placebo-controlled trial.","description":"<h4>Background</h4>With an aging population, knee arthroplasty is increasingly common; however, chronic postsurgical pain (CPSP) affects up to 30% of patients. This study aims to evaluate the efficacy of 5% lidocaine-medicated plaster (LP5) in preventing CPSP among patients undergoing knee arthroplasty.<h4>Methods</h4>This is a dual-center, randomized, double-blind, placebo-controlled trial involving 128 adult patients scheduled for knee arthroplasty. Participants will be randomly assigned, stratified by center, to either the LP5 group or the placebo group (n = 64 per group). The LP5 or placebo group will apply the patch 1 day before surgery and on postoperative days 1-3, with multimodal analgesia administered postoperatively. Multimodal analgesia will include intraoperative flurbiprofen a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-16T19:55:01.525Z","creation":"2025-04-06T11:46:17.964Z"},"accession":"S-EPMC11540780","cross_references":{"pubmed":["39512815"],"doi":["10.3389/fphar.2024.1486217"]}}