biostudies-literatureUnknown8(21)Zhang L<h4>Abstract</h4>According to the diagnostic criteria for human herpesvirus 8 (HHV-8)-negative/idiopathic multicentric Castleman disease (iMCD) proposed by Castleman Disease Collaborative Network in 2017, there is a group of HHV-8-negative patients with multicentric Castleman disease (MCD) who do not have symptoms and hyperinflammatory state and do not meet the iMCD criteria. This retrospective study enrolled 114 such patients, described as asymptomatic MCD (aMCD), from 26 Chinese centers from 2000 to 2021. With a median follow-up time of 46.5 months (range, 4-279 months), 6 patients (5.3%) transformed to iMCD. The median time between a diagnosis of aMCD and iMCD in these 6 patients was 28.5 months (range, 3-60). During follow-up, 7 patients died; 3 of them died from progression of MCD. DeBlood advances5598-5602https://www.ebi.ac.uk/biostudies/studies/S-EPMC11541685biostudies-literatureAsymptomatic multicentric Castleman disease: a potential early stage of idiopathic MCD.PMC11541685Dong YJWang XBZhong LYLi ZLZhang LHuang LGao GXGao DLiu YLiu QHWang HHZhou HPeng HLHuang WRDing KYWang LQLi JYan XJYang LSu LPQian WBZhang HLSong JSun CYLi YBi LTZhang MZfalseAsymptomatic multicentric Castleman disease: a potential early stage of idiopathic MCD.<h4>Abstract</h4>According to the diagnostic criteria for human herpesvirus 8 (HHV-8)-negative/idiopathic multicentric Castleman disease (iMCD) proposed by Castleman Disease Collaborative Network in 2017, there is a group of HHV-8-negative patients with multicentric Castleman disease (MCD) who do not have symptoms and hyperinflammatory state and do not meet the iMCD criteria. This retrospective study enrolled 114 such patients, described as asymptomatic MCD (aMCD), from 26 Chinese centers from 2000 to 2021. With a median follow-up time of 46.5 months (range, 4-279 months), 6 patients (5.3%) transformed to iMCD. The median time between a diagnosis of aMCD and iMCD in these 6 patients was 28.5 months (range, 3-60). During follow-up, 7 patients died; 3 of them died from progression of MCD. De2024-01-01T00:00:00Z2024 Nov2025-04-04T14:57:17.23Z2025-04-04T14:57:17.23ZS-EPMC115416853929308410.1182/bloodadvances.2024013728