biostudies-literatureLan ZNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNIAMS NIH HHS465-477https://www.ebi.ac.uk/biostudies/studies/S-EPMC11542385biostudies-literatureUnknown111(4)A major challenge in chronic wound treatment is maintaining an appropriate wound moisture balance throughout the healing process. Wound dehydration hinders wound healing due to impeded molecule transport and cell migration with associated tissue necrosis. In contrast, wounds that produce excess fluid contain high levels of reactive oxygen species and matrix metalloproteases that impede cell recruitment, extracellular matrix reconstruction, and angiogenesis. Dressings are currently selected based on the relative amount of wound exudate with no universal dressing available that can maintain appropriate wound moisture balance to enhance healing. This work aimed to develop a high porosity poly(ethylene glycol) diacrylate hydrogel foam that can both rapidly remove exudate and provide self-tuninJournal of biomedical materials research. Part AHigh porosity PEG-based hydrogel foams with self-tuning moisture balance as chronic wound dressings.PMC11542385R21 AR076107Kar RShoga EChwatko MCosgriff-Hernandez ELan ZfalseHigh porosity PEG-based hydrogel foams with self-tuning moisture balance as chronic wound dressings.A major challenge in chronic wound treatment is maintaining an appropriate wound moisture balance throughout the healing process. Wound dehydration hinders wound healing due to impeded molecule transport and cell migration with associated tissue necrosis. In contrast, wounds that produce excess fluid contain high levels of reactive oxygen species and matrix metalloproteases that impede cell recruitment, extracellular matrix reconstruction, and angiogenesis. Dressings are currently selected based on the relative amount of wound exudate with no universal dressing available that can maintain appropriate wound moisture balance to enhance healing. This work aimed to develop a high porosity poly(ethylene glycol) diacrylate hydrogel foam that can both rapidly remove exudate and provide self-tunin2023-01-01T00:00:00Z2023 Apr2025-04-06T23:11:44.52Z2025-04-04T09:36:53.352ZS-EPMC115423853660633210.1002/jbm.a.37498