{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Ma M"],"pubmed_abstract":["The quality of broiler meat affects consumers' purchasing decisions. Numerous studies have shown that phosphorylation of proteins in muscle can affect muscle quality. Here, metabolomics and transcriptomics were used to systematically identify the genetic regulation of differences in meat flavor among different broiler. By constructing the meat flavor-related metabolite-gene networks, we identified that protein phosphatase magnesium/manganese-dependent 1J (PPM1J), which is known to regulate a range of biological processes by modulating reversible protein phosphorylation, was a differentially expressed gene with the highest connectivity to meat flavor-related metabolites. Gain- and loss-of-function analysis revealed that PPM1J induced muscular atrophy, improved meat quality and regulated the"],"journal":["NPJ science of food"],"pagination":["89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11544016"],"repository":["biostudies-literature"],"pubmed_title":["PPM1J regulates meat quality feature and glycerophospholipids composition in broiler by modulating protein dephosphorylation."],"pmcid":["PMC11544016"],"pubmed_authors":["Yang X","Cai B","Ma M","Zhang Y","Wang S","Jin C","Chen W","Zheng C","Xia W"],"additional_accession":[]},"is_claimable":false,"name":"PPM1J regulates meat quality feature and glycerophospholipids composition in broiler by modulating protein dephosphorylation.","description":"The quality of broiler meat affects consumers' purchasing decisions. Numerous studies have shown that phosphorylation of proteins in muscle can affect muscle quality. Here, metabolomics and transcriptomics were used to systematically identify the genetic regulation of differences in meat flavor among different broiler. By constructing the meat flavor-related metabolite-gene networks, we identified that protein phosphatase magnesium/manganese-dependent 1J (PPM1J), which is known to regulate a range of biological processes by modulating reversible protein phosphorylation, was a differentially expressed gene with the highest connectivity to meat flavor-related metabolites. Gain- and loss-of-function analysis revealed that PPM1J induced muscular atrophy, improved meat quality and regulated the","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-22T19:42:39.73Z","creation":"2025-04-06T02:54:20.937Z"},"accession":"S-EPMC11544016","cross_references":{"pubmed":["39511232"],"doi":["10.1038/s41538-024-00335-1"]}}