{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(10)"],"submitter":["Yin L"],"pubmed_abstract":["Purinergic signaling plays a causal role in the modulation of immune inflammatory response in the course of psoriasis, but its regulatory mechanism remains unclear. As a member of purinoceptors, P2Y<sub>6</sub>R mainly distributed in macrophages was significantly up-expressed in skin lesions from patients with psoriasis in the present study. Here, the severity of psoriasis was alleviated in imiquimod-treated mice with macrophages conditional knockout of P2Y<sub>6</sub>R, while the cell-chat algorithm showed there was a correlation between macrophage P2Y<sub>6</sub>R and Th1 cells mediated by IL-27. Mechanistically, P2Y<sub>6</sub>R enhanced PLC <sub><i>β</i></sub> /p-PKC/MAPK activation to induce IL-27 release dependently, which subsequently regulated the differentiation of Th1 cells, lead"],"journal":["Acta pharmaceutica Sinica. B"],"pagination":["4360-4377"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11544167"],"repository":["biostudies-literature"],"pubmed_title":["Macrophage P2Y&lt;sub&gt;6&lt;/sub&gt;R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses."],"pmcid":["PMC11544167"],"pubmed_authors":["Zhou M","Li H","Zhang E","Ni K","Mao T","Zhu Y","Lu Y","Ni S","Fang Y","Li Y","Liu C","Hu Q","Yin L"],"additional_accession":[]},"is_claimable":false,"name":"Macrophage P2Y&lt;sub&gt;6&lt;/sub&gt;R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses.","description":"Purinergic signaling plays a causal role in the modulation of immune inflammatory response in the course of psoriasis, but its regulatory mechanism remains unclear. As a member of purinoceptors, P2Y<sub>6</sub>R mainly distributed in macrophages was significantly up-expressed in skin lesions from patients with psoriasis in the present study. Here, the severity of psoriasis was alleviated in imiquimod-treated mice with macrophages conditional knockout of P2Y<sub>6</sub>R, while the cell-chat algorithm showed there was a correlation between macrophage P2Y<sub>6</sub>R and Th1 cells mediated by IL-27. Mechanistically, P2Y<sub>6</sub>R enhanced PLC <sub><i>β</i></sub> /p-PKC/MAPK activation to induce IL-27 release dependently, which subsequently regulated the differentiation of Th1 cells, lead","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-22T16:25:05.127Z","creation":"2025-04-06T01:45:20.727Z"},"accession":"S-EPMC11544167","cross_references":{"pubmed":["39525587"],"doi":["10.1016/j.apsb.2024.06.008"]}}