{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang H"],"funding":["Chongqing Modern Agricultural Industry Technology System","Fundamental Research Funds for the Central University","Chongqing Modern • Agricultural Industry Technology System","National Natural Science Foundation of China","Strategic Priority Research Program of the National Center of Technology Innovation for Pigs"],"pagination":["3159"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11545170"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(21)"],"pubmed_abstract":["As a global focus of animal husbandry, pigs provide essential meat resources for humans. Therefore, analyzing the genetic basis of adaptability, domestication, and artificial selection in pigs will contribute to further breeding. This study performed a genome-wide selection sweep analysis to identify candidate genes related to domestication and adaptive selection via data from 2413 public genotypes. Two complementary statistical analyses, <i>F<sub>ST</sub></i> (fixation index) and XP-EHH (cross-population extended haplotype homozygosity) were applied. The results revealed that numerous candidate genes were associated with high-altitude adaptability (e.g., <i>SIRPA</i>, <i>FRS2</i>, and <i>GRIN2B</i>) and habitat temperature adaptability (e.g., <i>MITF</i>, <i>PI3KC2A</i>, and <i>FRS2</i>)."],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Genomic Insights into Pig Domestication and Adaptation: An Integrated Approach Using Genome-Wide Selection Analysis and Multiple Public Datasets."],"pmcid":["PMC11545170"],"funding_grant_id":["SWU-XDJH202301","32172696","NCTIP-XD/B01","COMAITS202312"],"pubmed_authors":["Xu L","Zhang D","Zhang H","Cong H","Yang B","Han Y","Ruan P","Chen H","Zeng Y","E G","Zhao Y","Pan H","Yang X","Ceccobelli S","Ren T","Liu D","Wang Z","Hu P"],"additional_accession":[]},"is_claimable":false,"name":"Genomic Insights into Pig Domestication and Adaptation: An Integrated Approach Using Genome-Wide Selection Analysis and Multiple Public Datasets.","description":"As a global focus of animal husbandry, pigs provide essential meat resources for humans. Therefore, analyzing the genetic basis of adaptability, domestication, and artificial selection in pigs will contribute to further breeding. This study performed a genome-wide selection sweep analysis to identify candidate genes related to domestication and adaptive selection via data from 2413 public genotypes. Two complementary statistical analyses, <i>F<sub>ST</sub></i> (fixation index) and XP-EHH (cross-population extended haplotype homozygosity) were applied. The results revealed that numerous candidate genes were associated with high-altitude adaptability (e.g., <i>SIRPA</i>, <i>FRS2</i>, and <i>GRIN2B</i>) and habitat temperature adaptability (e.g., <i>MITF</i>, <i>PI3KC2A</i>, and <i>FRS2</i>).","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-04-19T03:22:24.534Z","creation":"2025-04-04T23:32:24.938Z"},"accession":"S-EPMC11545170","cross_references":{"pubmed":["39518882"],"doi":["10.3390/ani14213159"]}}