{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang AS"],"funding":["Food and Health Bureau","Research Talent Hub for ITF Projects, Hong Kong"],"pagination":["250"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11545508"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Upper digestive tract cancers, such as oral cavity, laryngeal, esophageal, and gastric cancers, account for 10% of cancer cases and 14.5% of cancer-related deaths worldwide. Conventional treatments often provide limited survival benefits and are frequently associated with adverse effects and drug resistance. Chinese herbal drugs (CHDs) are widely used in the Far East for managing these cancers. In this narrative review, we summarize current clinical studies (published up to June 2024) on the use of 138 CHDs in the treatment of cancers and precancerous lesions of the upper digestive tract. For cancer treatment, 126 CHDs were tested, all in combination with conventional therapies. Each CHD increased the clinical efficacy and/or reduced the adverse effects of conventional therapies. The five-"],"journal":["Molecular cancer"],"pubmed_title":["Traditional Chinese medicine in treating upper digestive tract cancers."],"pmcid":["PMC11545508"],"funding_grant_id":["No.PiH/107/24","19200791"],"pubmed_authors":["Wu J","Huang AS","Fu XQ","Yu ZL","Amin A"],"additional_accession":[]},"is_claimable":false,"name":"Traditional Chinese medicine in treating upper digestive tract cancers.","description":"Upper digestive tract cancers, such as oral cavity, laryngeal, esophageal, and gastric cancers, account for 10% of cancer cases and 14.5% of cancer-related deaths worldwide. Conventional treatments often provide limited survival benefits and are frequently associated with adverse effects and drug resistance. Chinese herbal drugs (CHDs) are widely used in the Far East for managing these cancers. In this narrative review, we summarize current clinical studies (published up to June 2024) on the use of 138 CHDs in the treatment of cancers and precancerous lesions of the upper digestive tract. For cancer treatment, 126 CHDs were tested, all in combination with conventional therapies. Each CHD increased the clinical efficacy and/or reduced the adverse effects of conventional therapies. The five-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-16T19:48:42.625Z","creation":"2025-04-06T02:52:58.676Z"},"accession":"S-EPMC11545508","cross_references":{"pubmed":["39516786"],"doi":["10.1186/s12943-024-02149-x"]}}