biostudies-literatureYang HRural Revitalization Strategy Seed Industry Revitalization Project-Guangdong Southern Medicine Seed Industry Innovation Park3383https://www.ebi.ac.uk/biostudies/studies/S-EPMC11545744biostudies-literatureUnknown13(21)<i>Mesona chinensis</i> Benth. (or <i>Platostoma palustre</i> (<i>Blume</i>) A. J. Paton), an edible and medicinal plant, is the main ingredient in black jelly, Hsian-tsao tea, and beverages, and its processed products are popular in China as well as in Southeast Asian countries. Previous studies have shown that the alcohol extract of <i>Mesona chinensis</i> Benth. (MC) can reduce the accumulation of oleic acid and ameliorate hyperlipidemia. However, researchers have not yet determined whether it could improve intestinal permeability and metabolic dysfunction by controlling gut microbial dysbiosis and thus reducing hyperlipidemia. This study aimed to explore the potential mechanism by which MC regulates metabolic function disorders in hyperlipidemic high-fat diet (HFD)-fed rats and mice frFoods (Basel, Switzerland)<i>Mesona chinensis</i> Benth. Extract Ameliorates Hyperlipidemia in High-Fat Diet-Fed Mice and Rats by Regulating the Gut Microbiota.PMC11545744No. 2022-NJS-00-002, Guangdong Finance and Agriculture [2022] No. 184Yang HYang JLuo QLi JYu BLin CYan PZhan RHuang XFeng YDu JSong Xfalse<i>Mesona chinensis</i> Benth. Extract Ameliorates Hyperlipidemia in High-Fat Diet-Fed Mice and Rats by Regulating the Gut Microbiota.<i>Mesona chinensis</i> Benth. (or <i>Platostoma palustre</i> (<i>Blume</i>) A. J. Paton), an edible and medicinal plant, is the main ingredient in black jelly, Hsian-tsao tea, and beverages, and its processed products are popular in China as well as in Southeast Asian countries. Previous studies have shown that the alcohol extract of <i>Mesona chinensis</i> Benth. (MC) can reduce the accumulation of oleic acid and ameliorate hyperlipidemia. However, researchers have not yet determined whether it could improve intestinal permeability and metabolic dysfunction by controlling gut microbial dysbiosis and thus reducing hyperlipidemia. This study aimed to explore the potential mechanism by which MC regulates metabolic function disorders in hyperlipidemic high-fat diet (HFD)-fed rats and mice fr2024-01-01T00:00:00Z2024 Oct2026-07-09T13:27:39.998Z2025-04-04T14:50:58.282ZS-EPMC115457443951716710.3390/foods13213383