{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klyucherev TO"],"funding":["the Ministry of Science and Higher Education of the Russian Federation"],"pagination":["11564"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11545893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(21)"],"pubmed_abstract":["Osteoarthritis (OA) is a degenerative joint disease with limited therapeutic options, where inflammation plays a critical role in disease progression. Extracellular vesicles (EV) derived from mesenchymal stromal cells (MSC) have shown potential as a therapeutic approach for OA by modulating inflammation and alleviating degenerative processes in the joint. This study evaluated the therapeutic effects for the treatment of OA of two types of EV-exosomes and matrix-bound nanovesicles (MBV)-both derived from the human umbilical cord MSC (UC-MSC) via differential ultracentrifugation. Different phenotypes of human monocyte-derived macrophages (MDM) were used to study the anti-inflammatory properties of EV in vitro, and the medial meniscectomy-induced rat model of knee osteoarthritis (MMx) was use"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Therapeutic Potential of Exosomes vs. Matrix-Bound Nanovesicles from Human Umbilical Cord Mesenchymal Stromal Cells in Osteoarthritis Treatment."],"pmcid":["PMC11545893"],"funding_grant_id":["075-15-2024-640 (Sechenov University)"],"pubmed_authors":["Vlasova II","Svistunov AA","Revokatova DP","Peshkova MA","Fayzullin AL","Kosheleva NV","Fayzullina NM","Klyucherev TO","Serejnikova NB","Ershov BP","Khristidis YI","Timashev PS"],"additional_accession":[]},"is_claimable":false,"name":"The Therapeutic Potential of Exosomes vs. Matrix-Bound Nanovesicles from Human Umbilical Cord Mesenchymal Stromal Cells in Osteoarthritis Treatment.","description":"Osteoarthritis (OA) is a degenerative joint disease with limited therapeutic options, where inflammation plays a critical role in disease progression. Extracellular vesicles (EV) derived from mesenchymal stromal cells (MSC) have shown potential as a therapeutic approach for OA by modulating inflammation and alleviating degenerative processes in the joint. This study evaluated the therapeutic effects for the treatment of OA of two types of EV-exosomes and matrix-bound nanovesicles (MBV)-both derived from the human umbilical cord MSC (UC-MSC) via differential ultracentrifugation. Different phenotypes of human monocyte-derived macrophages (MDM) were used to study the anti-inflammatory properties of EV in vitro, and the medial meniscectomy-induced rat model of knee osteoarthritis (MMx) was use","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T00:38:49.729Z","creation":"2025-04-04T00:38:49.729Z"},"accession":"S-EPMC11545893","cross_references":{"pubmed":["39519121"],"doi":["10.3390/ijms252111564"]}}