{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Diaz-Saez F"],"funding":["Generalitat de Catalunya","CIBERDEM Instituto de Salud Carlos III","Fundación Ramón Areces","Fundació La Marató de TV3","MICINN"],"pagination":["11718"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11546241"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(21)"],"pubmed_abstract":["Neuregulin 4 (Nrg4) is an adipokine that belongs to the epidermal growth factor family and binds to ErbB4 tyrosine kinase receptors. In 3T3-L1 adipocytes, the downregulation of <i>Nrg4</i> expression enhances inflammation and autophagy, resulting in insulin resistance. Here, we searched for the causes of this phenotype. Nrg4 knockdown (Nrg4 KD) adipocytes showed a significant reduction in mitochondrial content and elongation, along with a lower content of the mitochondria fusion protein mitofusin 2 (MFN2), and increased H<sub>2</sub>O<sub>2</sub> production compared to the control scrambled cells (Scr). The antioxidant N-acetylcysteine reversed the oxidative stress and reduced the gene expression of the pro-inflammatory cytokine tumor necrosis factor α (TNFα). Nrg4 KD adipocytes showed enh"],"journal":["International journal of molecular sciences"],"pubmed_title":["Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes."],"pmcid":["PMC11546241"],"funding_grant_id":["XX","534/C/2016","PID2019-106209RB-100","201626-30","PID2022-137576OB-100","CIVP18A3942"],"pubmed_authors":["Camps M","Balcells C","Ricart W","Diaz-Saez F","Romero M","Guma A","Lopez-Soldado I","Sebastian D","Moreno-Navarrete JM","Fernandez-Real JM","Aragones J","Rossello L","Zorzano A","Cascante M","Busquets S","Lopez-Soriano FJ","Testar X"],"additional_accession":[]},"is_claimable":false,"name":"Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes.","description":"Neuregulin 4 (Nrg4) is an adipokine that belongs to the epidermal growth factor family and binds to ErbB4 tyrosine kinase receptors. In 3T3-L1 adipocytes, the downregulation of <i>Nrg4</i> expression enhances inflammation and autophagy, resulting in insulin resistance. Here, we searched for the causes of this phenotype. Nrg4 knockdown (Nrg4 KD) adipocytes showed a significant reduction in mitochondrial content and elongation, along with a lower content of the mitochondria fusion protein mitofusin 2 (MFN2), and increased H<sub>2</sub>O<sub>2</sub> production compared to the control scrambled cells (Scr). The antioxidant N-acetylcysteine reversed the oxidative stress and reduced the gene expression of the pro-inflammatory cytokine tumor necrosis factor α (TNFα). Nrg4 KD adipocytes showed enh","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-12T03:14:02.077Z","creation":"2025-04-06T01:45:39.689Z"},"accession":"S-EPMC11546241","cross_references":{"pubmed":["39519269"],"doi":["10.3390/ijms252111718"]}}