biostudies-literatureLi CNatural Science Foundation of Shandong ProvinceJinan Clinical Medical Science and Technology Innovation PlanShandong Province Major Scientific and Technical Innovation Project896https://www.ebi.ac.uk/biostudies/studies/S-EPMC11546262biostudies-literatureUnknown25(1)<h4>Background</h4>This study aims to evaluate the efficacy and clinical outcomes of Nice knot-assisted fixation in the management of comminuted and displaced clavicle fractures.<h4>Methods</h4>A systematic search was conducted across multiple electronic databases, including PubMed, Embase, Cochrane Library, China Biology Medicine (CBM) database, CNKI, Wanfang, and VIP database, to identify studies comparing Nice knot-assisted fixation with traditional surgical treatment for displaced midshaft clavicle fractures. The primary outcomes assessed included fracture healing times, hospitalization days, complications, and functional outcomes. Secondary outcomes such as intraoperative blood loss, operative time, incision length, and fluoroscopy time were also evaluated. Data were analyzed using raBMC musculoskeletal disordersNice knots assistance in comminuted and displaced clavicle fractures reduce intraoperative blood and shorten operation time with a satisfactory postoperative clinical outcome.PMC11546262ZR2021QH307202328065No.: ZR2021MH0132021SFGC0502Li CCao WDong JKou HLi LLiu FfalseNice knots assistance in comminuted and displaced clavicle fractures reduce intraoperative blood and shorten operation time with a satisfactory postoperative clinical outcome.<h4>Background</h4>This study aims to evaluate the efficacy and clinical outcomes of Nice knot-assisted fixation in the management of comminuted and displaced clavicle fractures.<h4>Methods</h4>A systematic search was conducted across multiple electronic databases, including PubMed, Embase, Cochrane Library, China Biology Medicine (CBM) database, CNKI, Wanfang, and VIP database, to identify studies comparing Nice knot-assisted fixation with traditional surgical treatment for displaced midshaft clavicle fractures. The primary outcomes assessed included fracture healing times, hospitalization days, complications, and functional outcomes. Secondary outcomes such as intraoperative blood loss, operative time, incision length, and fluoroscopy time were also evaluated. Data were analyzed using ra2024-01-01T00:00:00Z2024 Nov2026-07-09T13:23:50.824Z2025-04-04T18:55:42.84ZS-EPMC115462623951674310.1186/s12891-024-08012-w