biostudies-literatureChen SNational Natural Science Foundation of ChinaScience and Technology Plan Project of Sichuan ProvincePublic Project of Zhejiang Province11533https://www.ebi.ac.uk/biostudies/studies/S-EPMC11546323biostudies-literatureUnknown25(21)Perchlorate is one of the major inorganic pollutants in the natural environment and the living environment, which is toxic to organisms and difficult to degrade due to its special structure. As previously reported, the Phoenix Mars lander detected approximately 0.6% perchlorate in the Martian soil, indicating challenges for Earth-based life to survive there. Currently, biological approaches using dissimilatory perchlorate-reducing bacteria (DPRB) are the most promising methods for perchlorate degradation. However, the majority of DPRB exhibit limited radiation resistance, rendering them unsuitable for survival on Mars. In this study, we obtained the transcriptome data of <i>Deinococcus deserti</i>, and predicted and identified multiple constitutive expression promoters of <i>D</i>. <i>deseInternational journal of molecular sciencesThe Construction of an Extreme Radiation-Resistant Perchlorate-Reducing Bacterium Using <i>Deinococcus deserti</i> Promoters.PMC11546323323700282024YFHZ20047LGN22C010002Hua YWang BTan ZTian BChen SXu HZhao YWang LfalseThe Construction of an Extreme Radiation-Resistant Perchlorate-Reducing Bacterium Using <i>Deinococcus deserti</i> Promoters.Perchlorate is one of the major inorganic pollutants in the natural environment and the living environment, which is toxic to organisms and difficult to degrade due to its special structure. As previously reported, the Phoenix Mars lander detected approximately 0.6% perchlorate in the Martian soil, indicating challenges for Earth-based life to survive there. Currently, biological approaches using dissimilatory perchlorate-reducing bacteria (DPRB) are the most promising methods for perchlorate degradation. However, the majority of DPRB exhibit limited radiation resistance, rendering them unsuitable for survival on Mars. In this study, we obtained the transcriptome data of <i>Deinococcus deserti</i>, and predicted and identified multiple constitutive expression promoters of <i>D</i>. <i>dese2024-01-01T00:00:00Z2024 Oct2026-04-22T03:22:59.013Z2025-04-06T22:42:54.011ZS-EPMC115463233951908610.3390/ijms252111533