{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie J"],"funding":["Basic and Applied Basic Research Foundation of Guangdong Province"],"pagination":["232"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11546403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Diabetic wounds pose a challenge to healing due to increased bacterial susceptibility and poor vascularization. Effective healing requires simultaneous bacterial and biofilm elimination and angiogenesis stimulation. In this study, we incorporated polyaniline (PANI) and S-Nitrosoglutathione (GSNO) into a polyvinyl alcohol, chitosan, and hydroxypropyltrimethyl ammonium chloride chitosan (PVA/CS/HTCC) matrix, creating a versatile wound dressing membrane through electrospinning. The dressing combines the advantages of photothermal antibacterial therapy and nitric oxide gas therapy, exhibiting enduring and effective bactericidal activity and biofilm disruption against methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Escherichia coli. Furthermore, the"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["NIR-activated electrospun nanodetonator dressing enhances infected diabetic wound healing with combined photothermal and nitric oxide-based gas therapy."],"pmcid":["PMC11546403"],"funding_grant_id":["2022A1515140189"],"pubmed_authors":["Tang Z","Li H","Lei M","Wang D","Zhong Q","Huang Y","Zhang Y","Xie J","Mai H","Ning Y","Fu J","Chen R","Cheng H","Liu G","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"NIR-activated electrospun nanodetonator dressing enhances infected diabetic wound healing with combined photothermal and nitric oxide-based gas therapy.","description":"Diabetic wounds pose a challenge to healing due to increased bacterial susceptibility and poor vascularization. Effective healing requires simultaneous bacterial and biofilm elimination and angiogenesis stimulation. In this study, we incorporated polyaniline (PANI) and S-Nitrosoglutathione (GSNO) into a polyvinyl alcohol, chitosan, and hydroxypropyltrimethyl ammonium chloride chitosan (PVA/CS/HTCC) matrix, creating a versatile wound dressing membrane through electrospinning. The dressing combines the advantages of photothermal antibacterial therapy and nitric oxide gas therapy, exhibiting enduring and effective bactericidal activity and biofilm disruption against methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Escherichia coli. Furthermore, the","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-07-16T15:05:45.204Z","creation":"2025-04-05T23:12:13.683Z"},"accession":"S-EPMC11546403","cross_references":{"pubmed":["38720301"],"doi":["10.1186/s12951-024-02474-9"]}}