{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie J"],"funding":["National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["11852"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11546743"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(21)"],"pubmed_abstract":["Hemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance. Herein, we sequenced five tissues (gill, liver, intestine, kidney, and muscle) from grass carp before and after GCRV infection using data-independent acquisition proteomic and untargeted metabolomic technologies, and quantitatively identified 10,808 proteins and 4040 metabolites. Then, we analyzed the differentially expressed proteins (DEPs) and metabolites (DEMs) before and after GCRV infection in the five tissues. Gene ontology analysis revealed that the five tissue DEPs were enriched in metabolic, including carbohydrate and lipid metabolic processes. Chemical taxonomy ana"],"journal":["International journal of molecular sciences"],"pubmed_title":["Analysis of GCRV Pathogenesis and Therapeutic Measures Through Proteomic and Metabolomic Investigations in GCRV-Infected Tissues of Grass Carp (<i>Ctenopharyngodon idella</i>)."],"pmcid":["PMC11546743"],"funding_grant_id":["32373120","2023YFD2401603"],"pubmed_authors":["Li Y","Liao L","Zhu Z","Xie J","Wang Y","Huang R","Jia Z"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of GCRV Pathogenesis and Therapeutic Measures Through Proteomic and Metabolomic Investigations in GCRV-Infected Tissues of Grass Carp (<i>Ctenopharyngodon idella</i>).","description":"Hemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance. Herein, we sequenced five tissues (gill, liver, intestine, kidney, and muscle) from grass carp before and after GCRV infection using data-independent acquisition proteomic and untargeted metabolomic technologies, and quantitatively identified 10,808 proteins and 4040 metabolites. Then, we analyzed the differentially expressed proteins (DEPs) and metabolites (DEMs) before and after GCRV infection in the five tissues. Gene ontology analysis revealed that the five tissue DEPs were enriched in metabolic, including carbohydrate and lipid metabolic processes. Chemical taxonomy ana","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-12T03:17:00.136Z","creation":"2025-04-06T01:46:15.948Z"},"accession":"S-EPMC11546743","cross_references":{"pubmed":["39519403"],"doi":["10.3390/ijms252111852"]}}