{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Benzenine D"],"funding":["Ministerio de Ciencia y Tecnología","Directorate General for Scientific Research and Technological Development (DGRSDT)","University of Tlemcen"],"pagination":["5058"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11547262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(21)"],"pubmed_abstract":["A convenient and effective synthesis of imidazo[1,2-<i>a</i>]pyrimidine derivatives has been developed under microwave irradiations using Al<sub>2</sub>O<sub>3</sub> as a catalyst in solvent-free conditions. The functionalized imidazo[1,2-<i>a</i>]pyrimidine derivatives are useful in biochemistry and medical science. In our investigation, the antimicrobial activity of the synthesized compounds was evaluated against 13 microorganisms, including 6 Gram-positive bacteria, 4 Gram-negative bacteria, and 3 pathogenic fungi. Bioactivity tests revealed that the majority of the compounds exhibited good antimicrobial activity. Finally, molecular docking simulations and ADME-T predictions were performed, showing that the most active compounds have good binding modes with microbial targets and promisi"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Design, Synthesis, Molecular Docking, and ADME-Tox Investigations of Imidazo[1,2-a]Pyrimidines Derivatives as Antimicrobial Agents."],"pmcid":["PMC11547262"],"funding_grant_id":["MAT2017-86109P"],"pubmed_authors":["Benzenine D","Seijas JA","Vazquez-Tato MP","Choukchou-Braham N","Daoud I","Ziani-Cherif C","Belarbi L","Aissaoui N","Kibou Z"],"additional_accession":[]},"is_claimable":false,"name":"Design, Synthesis, Molecular Docking, and ADME-Tox Investigations of Imidazo[1,2-a]Pyrimidines Derivatives as Antimicrobial Agents.","description":"A convenient and effective synthesis of imidazo[1,2-<i>a</i>]pyrimidine derivatives has been developed under microwave irradiations using Al<sub>2</sub>O<sub>3</sub> as a catalyst in solvent-free conditions. The functionalized imidazo[1,2-<i>a</i>]pyrimidine derivatives are useful in biochemistry and medical science. In our investigation, the antimicrobial activity of the synthesized compounds was evaluated against 13 microorganisms, including 6 Gram-positive bacteria, 4 Gram-negative bacteria, and 3 pathogenic fungi. Bioactivity tests revealed that the majority of the compounds exhibited good antimicrobial activity. Finally, molecular docking simulations and ADME-T predictions were performed, showing that the most active compounds have good binding modes with microbial targets and promisi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-04-08T19:36:04.065Z","creation":"2025-04-04T11:42:06.516Z"},"accession":"S-EPMC11547262","cross_references":{"pubmed":["39519699"],"doi":["10.3390/molecules29215058"]}}