biostudies-literatureBenzenine DMinisterio de Ciencia y TecnologíaDirectorate General for Scientific Research and Technological Development (DGRSDT)University of Tlemcen5058https://www.ebi.ac.uk/biostudies/studies/S-EPMC11547262biostudies-literatureUnknown29(21)A convenient and effective synthesis of imidazo[1,2-<i>a</i>]pyrimidine derivatives has been developed under microwave irradiations using Al₂O₃ as a catalyst in solvent-free conditions. The functionalized imidazo[1,2-<i>a</i>]pyrimidine derivatives are useful in biochemistry and medical science. In our investigation, the antimicrobial activity of the synthesized compounds was evaluated against 13 microorganisms, including 6 Gram-positive bacteria, 4 Gram-negative bacteria, and 3 pathogenic fungi. Bioactivity tests revealed that the majority of the compounds exhibited good antimicrobial activity. Finally, molecular docking simulations and ADME-T predictions were performed, showing that the most active compounds have good binding modes with microbial targets and promisiMolecules (Basel, Switzerland)Design, Synthesis, Molecular Docking, and ADME-Tox Investigations of Imidazo[1,2-a]Pyrimidines Derivatives as Antimicrobial Agents.PMC11547262MAT2017-86109PBenzenine DSeijas JAVazquez-Tato MPChoukchou-Braham NDaoud IZiani-Cherif CBelarbi LAissaoui NKibou ZfalseDesign, Synthesis, Molecular Docking, and ADME-Tox Investigations of Imidazo[1,2-a]Pyrimidines Derivatives as Antimicrobial Agents.A convenient and effective synthesis of imidazo[1,2-<i>a</i>]pyrimidine derivatives has been developed under microwave irradiations using Al₂O₃ as a catalyst in solvent-free conditions. The functionalized imidazo[1,2-<i>a</i>]pyrimidine derivatives are useful in biochemistry and medical science. In our investigation, the antimicrobial activity of the synthesized compounds was evaluated against 13 microorganisms, including 6 Gram-positive bacteria, 4 Gram-negative bacteria, and 3 pathogenic fungi. Bioactivity tests revealed that the majority of the compounds exhibited good antimicrobial activity. Finally, molecular docking simulations and ADME-T predictions were performed, showing that the most active compounds have good binding modes with microbial targets and promisi2024-01-01T00:00:00Z2024 Oct2026-04-08T19:36:04.065Z2025-04-04T11:42:06.516ZS-EPMC115472623951969910.3390/molecules29215058