{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(21)"],"submitter":["Yada R"],"pubmed_abstract":["The present article describes the successful performance of crossed aldol reactions of the CF<sub>3</sub>-containing pseudo-C<sub>2</sub> symmetric cyclic imide with various aldehydes. The utilization of HMPA as an additive attained the preferential formation of the <i>anti</i>-products in good to excellent yields, which contrasts with our previous method without this additive, proceeding to furnish the corresponding <i>syn</i>-isomers. The effective participation of ketones and α,β-unsaturated carbonyl compounds in reactions with this imide was also demonstrated to expand the application of this imide."],"journal":["Molecules (Basel, Switzerland)"],"pagination":["5129"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11547649"],"repository":["biostudies-literature"],"pubmed_title":["Stereodivergent Synthesis of Aldol Products Using Pseudo-C<sub>2</sub> Symmetric <i>N</i>-benzyl-4-(trifluoromethyl)piperidine-2,6-dione."],"pmcid":["PMC11547649"],"pubmed_authors":["Yada R","Kawasaki-Takasuka T","Yamazaki T"],"additional_accession":[]},"is_claimable":false,"name":"Stereodivergent Synthesis of Aldol Products Using Pseudo-C<sub>2</sub> Symmetric <i>N</i>-benzyl-4-(trifluoromethyl)piperidine-2,6-dione.","description":"The present article describes the successful performance of crossed aldol reactions of the CF<sub>3</sub>-containing pseudo-C<sub>2</sub> symmetric cyclic imide with various aldehydes. The utilization of HMPA as an additive attained the preferential formation of the <i>anti</i>-products in good to excellent yields, which contrasts with our previous method without this additive, proceeding to furnish the corresponding <i>syn</i>-isomers. The effective participation of ketones and α,β-unsaturated carbonyl compounds in reactions with this imide was also demonstrated to expand the application of this imide.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-09T13:23:50.769Z","creation":"2025-04-04T14:51:09.873Z"},"accession":"S-EPMC11547649","cross_references":{"pubmed":["39519771"],"doi":["10.3390/molecules29215129"]}}