biostudies-literatureUnknown29(21)Yada RThe present article describes the successful performance of crossed aldol reactions of the CF₃-containing pseudo-C₂ symmetric cyclic imide with various aldehydes. The utilization of HMPA as an additive attained the preferential formation of the <i>anti</i>-products in good to excellent yields, which contrasts with our previous method without this additive, proceeding to furnish the corresponding <i>syn</i>-isomers. The effective participation of ketones and α,β-unsaturated carbonyl compounds in reactions with this imide was also demonstrated to expand the application of this imide.Molecules (Basel, Switzerland)5129https://www.ebi.ac.uk/biostudies/studies/S-EPMC11547649biostudies-literatureStereodivergent Synthesis of Aldol Products Using Pseudo-C₂ Symmetric <i>N</i>-benzyl-4-(trifluoromethyl)piperidine-2,6-dione.PMC11547649Yada RKawasaki-Takasuka TYamazaki TfalseStereodivergent Synthesis of Aldol Products Using Pseudo-C₂ Symmetric <i>N</i>-benzyl-4-(trifluoromethyl)piperidine-2,6-dione.The present article describes the successful performance of crossed aldol reactions of the CF₃-containing pseudo-C₂ symmetric cyclic imide with various aldehydes. The utilization of HMPA as an additive attained the preferential formation of the <i>anti</i>-products in good to excellent yields, which contrasts with our previous method without this additive, proceeding to furnish the corresponding <i>syn</i>-isomers. The effective participation of ketones and α,β-unsaturated carbonyl compounds in reactions with this imide was also demonstrated to expand the application of this imide.2024-01-01T00:00:00Z2024 Oct2026-07-09T13:23:50.769Z2025-04-04T14:51:09.873ZS-EPMC115476493951977110.3390/molecules29215129