biostudies-literatureArafa WAAAl Jouf University5114https://www.ebi.ac.uk/biostudies/studies/S-EPMC11547704biostudies-literatureUnknown29(21)Our novel binuclear complex-anchored Ru(III) catalyst, designed and assembled by sonicating 2,2'-(4,6-dihydroxy-1,3-phenylene)bis(1<i>H</i>-benzo[<i>d</i>]imidazole-4-carboxylic acid), Ru(DMSO)₄Cl₂ and 4-methylpyridine, demonstrates remarkable efficiency and selectivity. It promotes one-pot reactions, including active methylenes and benzyl alcohols in water, via a tandem aerobic oxidation/Knoevenagel condensation process, yielding benzylidene malononitrile in excellent yields. The catalyst's ability to oxidize benzyl alcohols to aldehydes, which then undergo Knoevenagel condensation with active methylenes, makes it a multifunctional catalyst. Notably, the catalyst can be successfully retrieved and recycled for five successive rounds with no significant decrease in catMolecules (Basel, Switzerland)A Ru-Based Complex for Sustainable One-Pot Tandem Aerobic Oxidation-Knoevenagel Condensation Reactions.PMC11547704DGSSR-2023-02-02344Arafa WAAMourad AKBrase SNayl AAYoussef AMSAhmed IMfalseA Ru-Based Complex for Sustainable One-Pot Tandem Aerobic Oxidation-Knoevenagel Condensation Reactions.Our novel binuclear complex-anchored Ru(III) catalyst, designed and assembled by sonicating 2,2'-(4,6-dihydroxy-1,3-phenylene)bis(1<i>H</i>-benzo[<i>d</i>]imidazole-4-carboxylic acid), Ru(DMSO)₄Cl₂ and 4-methylpyridine, demonstrates remarkable efficiency and selectivity. It promotes one-pot reactions, including active methylenes and benzyl alcohols in water, via a tandem aerobic oxidation/Knoevenagel condensation process, yielding benzylidene malononitrile in excellent yields. The catalyst's ability to oxidize benzyl alcohols to aldehydes, which then undergo Knoevenagel condensation with active methylenes, makes it a multifunctional catalyst. Notably, the catalyst can be successfully retrieved and recycled for five successive rounds with no significant decrease in cat2024-01-01T00:00:00Z2024 Oct2026-07-09T13:25:13.835Z2025-04-04T00:38:37.664ZS-EPMC115477043951975510.3390/molecules29215114