biostudies-literatureYang HJ"Food Functionality Evaluation program" under the Ministry of Agriculture, Food and Rural Affairs and partly the Korea Food Research Institute.3751https://www.ebi.ac.uk/biostudies/studies/S-EPMC11547720biostudies-literatureUnknown16(21)<h4>Background/objectives</h4><i>Schisandra chinensis</i> Fructus (SCF) is a traditional medicinal herb containing lignans that improves glucose metabolism by mitigating insulin resistance. We aimed to investigate the therapeutic potential and action mechanism of SCF for Alzheimer's disease (AD) using a network pharmacology analysis, followed by experimental validation in an AD rat model.<h4>Methods</h4>The biological activities of SCF's bioactive compounds were assessed through a network pharmacology analysis. An AD rat model was generated by infusing amyloid-β peptide (Aβ) (25-35) into the hippocampus to induce Aβ accumulation. The AD rats were fed either 0.5% dextrin (AD-Con) or 0.5% SCF (AD-SCF group) in a high-fat diet for seven weeks. The rats in the normal/control group received an NutrientsEfficacy and Mechanism of &lt;i&gt;Schisandra chinensis&lt;/i&gt; Fructus Water Extract in Alzheimer's Disease: Insights from Network Pharmacology and Validation in an Amyloid-β Infused Animal Model.PMC115477202023-2Zhang TJang DJKim MJHur HJPark SYang HJWu XfalseEfficacy and Mechanism of &lt;i&gt;Schisandra chinensis&lt;/i&gt; Fructus Water Extract in Alzheimer's Disease: Insights from Network Pharmacology and Validation in an Amyloid-β Infused Animal Model.<h4>Background/objectives</h4><i>Schisandra chinensis</i> Fructus (SCF) is a traditional medicinal herb containing lignans that improves glucose metabolism by mitigating insulin resistance. We aimed to investigate the therapeutic potential and action mechanism of SCF for Alzheimer's disease (AD) using a network pharmacology analysis, followed by experimental validation in an AD rat model.<h4>Methods</h4>The biological activities of SCF's bioactive compounds were assessed through a network pharmacology analysis. An AD rat model was generated by infusing amyloid-β peptide (Aβ) (25-35) into the hippocampus to induce Aβ accumulation. The AD rats were fed either 0.5% dextrin (AD-Con) or 0.5% SCF (AD-SCF group) in a high-fat diet for seven weeks. The rats in the normal/control group received an 2024-01-01T00:00:00Z2024 Oct2025-04-18T14:07:21.271Z2025-04-07T00:04:21.436ZS-EPMC115477203951958610.3390/nu16213751