biostudies-literatureUnknown2(3)Guo W<h4>Aims</h4>A new model of computational fluid dynamics (CFD)-based algorithm for coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) (CT-FFR) analysis by expanding the coronary tree to smaller-diameter lumen (0.8 mm) using Newton-Krylov-Schwarz (NKS) method to solve the three-dimensional time-dependent incompressible Navier-Stokes equations has been developed; however, the diagnostic performance of this new method has not been sufficiently investigated. The aim of this study was to determine the diagnostic performance of a novel CT-FFR technique by expanding the coronary tree in the CFD domain.<h4>Methods and results</h4>Six centres enrolled 338 symptomatic patients with suspected or known coronary artery disease (CAD) who prospectively underwent CCTA and FFR. Stenosis aEuropean heart journal. Imaging methods and practiceqyae106https://www.ebi.ac.uk/biostudies/studies/S-EPMC11547952biostudies-literatureCT-FFR by expanding coronary tree with Newton-Krylov-Schwarz method to solve the governing equations of CFD.PMC11547952Shen LWu JGao BLiu JJun JHuang JLu YGuo WHu XZhang HGe JWei WWang JCheng ZYao ZJin HYan ZLiang JWang XZhou HTong GChen RWu YLi CZeng MHe WYang RYang SYin JfalseCT-FFR by expanding coronary tree with Newton-Krylov-Schwarz method to solve the governing equations of CFD.<h4>Aims</h4>A new model of computational fluid dynamics (CFD)-based algorithm for coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) (CT-FFR) analysis by expanding the coronary tree to smaller-diameter lumen (0.8 mm) using Newton-Krylov-Schwarz (NKS) method to solve the three-dimensional time-dependent incompressible Navier-Stokes equations has been developed; however, the diagnostic performance of this new method has not been sufficiently investigated. The aim of this study was to determine the diagnostic performance of a novel CT-FFR technique by expanding the coronary tree in the CFD domain.<h4>Methods and results</h4>Six centres enrolled 338 symptomatic patients with suspected or known coronary artery disease (CAD) who prospectively underwent CCTA and FFR. Stenosis a2024-01-01T00:00:00Z2024 Jul2025-04-04T13:41:44.848Z2025-04-04T13:41:44.848ZS-EPMC115479523952551510.1093/ehjimp/qyae106