{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Đorđevic Zlatkovic MR"],"funding":["Ministry of Science, Technological Development and Innovations of the Republic of Serbia"],"pagination":["3045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11548152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(21)"],"pubmed_abstract":["An essential oil dominated by germacrene D (19.3% by GC) was isolated from the fresh fruit of <i>Amorpha fruticosa</i> L. (Fabaceae). Agglomerative clustering and <i>k</i>-means clustering were employed to compare the composition of the oil with the existing literature data, suggesting that the <i>A. fruticosa</i> used in this study represents a new chemotype. The essential oil was evaluated for its antinociceptive activity using the acetic acid-induced writhing test in rats at doses of 400, 200, and 100 mg/kg. All tested doses reduced the number of writhes induced by the intraperitoneal injection of acetic acid. The 400 mg/kg dose of the oil demonstrated a 54.4% inhibition, which was statistically different from the positive control, aspirin, which showed 90.2% inhibition at a dose of 200"],"journal":["Plants (Basel, Switzerland)"],"pubmed_title":["Chemodiversity and Antinociceptive Activity of <i>Amorpha fruticosa</i> L. Essential Oil."],"pmcid":["PMC11548152"],"funding_grant_id":["451-03-65/2024-03/200124, 451-03-66/2024-03/200124 and 451-03-65/2024-03/200113"],"pubmed_authors":["Radulovic NS","Stojanovic NM","Đorđevic Zlatkovic MR","Randjelovic PJ","Zlatkovic DB"],"additional_accession":[]},"is_claimable":false,"name":"Chemodiversity and Antinociceptive Activity of <i>Amorpha fruticosa</i> L. Essential Oil.","description":"An essential oil dominated by germacrene D (19.3% by GC) was isolated from the fresh fruit of <i>Amorpha fruticosa</i> L. (Fabaceae). Agglomerative clustering and <i>k</i>-means clustering were employed to compare the composition of the oil with the existing literature data, suggesting that the <i>A. fruticosa</i> used in this study represents a new chemotype. The essential oil was evaluated for its antinociceptive activity using the acetic acid-induced writhing test in rats at doses of 400, 200, and 100 mg/kg. All tested doses reduced the number of writhes induced by the intraperitoneal injection of acetic acid. The 400 mg/kg dose of the oil demonstrated a 54.4% inhibition, which was statistically different from the positive control, aspirin, which showed 90.2% inhibition at a dose of 200","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-09T13:25:31.964Z","creation":"2025-04-07T00:02:05.571Z"},"accession":"S-EPMC11548152","cross_references":{"pubmed":["39519963"],"doi":["10.3390/plants13213045"]}}