biostudies-literatureNegrescu AMRomanian Ministry of Education and Research, CCCDI-UEFISCDI3046https://www.ebi.ac.uk/biostudies/studies/S-EPMC11548769biostudies-literatureUnknown16(21)Since breast cancer is one of the most common forms of cancer in women, silicone mammary implants have been extensively employed in numerous breast reconstruction procedures. However, despite the crucial role they play, their interaction with the host's immune system and microbiome is poorly understood. Considering this, the present work investigates the immunomodulatory and bacterial mitigation potential of six textured surfaces, based on linear step-like features with various regular and irregular multiscaled arrangements, in comparison to a flat PDMS surface. We hypothesise that the chosen surface geometries are capable of modulating the cellular response through mechanical interdigitation within the multiscaled surface morphology, independent of the surface chemical properties. Each tyPolymersMacrophage Immunomodulation and Suppression of Bacterial Growth by Polydimethylsiloxane Surface-Interrupted Microlines' Topography Targeting Breast Implant Applications.PMC11548769PN-III-P4-ID-PCE-2020-2375Nistorescu SBonciu AFDumitrescu LNNegrescu AMUrzica IDinca VCimpean ARusen LfalseMacrophage Immunomodulation and Suppression of Bacterial Growth by Polydimethylsiloxane Surface-Interrupted Microlines' Topography Targeting Breast Implant Applications.Since breast cancer is one of the most common forms of cancer in women, silicone mammary implants have been extensively employed in numerous breast reconstruction procedures. However, despite the crucial role they play, their interaction with the host's immune system and microbiome is poorly understood. Considering this, the present work investigates the immunomodulatory and bacterial mitigation potential of six textured surfaces, based on linear step-like features with various regular and irregular multiscaled arrangements, in comparison to a flat PDMS surface. We hypothesise that the chosen surface geometries are capable of modulating the cellular response through mechanical interdigitation within the multiscaled surface morphology, independent of the surface chemical properties. Each ty2024-01-01T00:00:00Z2024 Oct2025-04-04T00:38:37.791Z2025-04-04T00:38:37.791ZS-EPMC115487693951825510.3390/polym16213046