biostudies-literatureForestieri NENCBDD CDC HHSCenters for Disease Control and PreventionNCI NIH HHSIntramural CDC HHSCDC HHSe2394https://www.ebi.ac.uk/biostudies/studies/S-EPMC11548799biostudies-literatureUnknown116(9)<h4>Background</h4>Critical congenital heart defects (CCHDs) are associated with considerable morbidity and mortality. This study estimated survival of children with nonsyndromic CCHDs and evaluated relationships between exposures of interest and survival by CCHD severity (univentricular or biventricular function).<h4>Methods</h4>This analysis included 4380 infants with CCHDs (cases) born during 1999-2011 and enrolled in the National Birth Defects Prevention Study, a multisite, population-based case-control study of major birth defects. Cases were linked to state death files. Nonparametric Kaplan-Meier survival functions were used to estimate 1- and 5-year survival probabilities overall and by severity group (univentricular/biventricular) stratified by demographic and clinical exposure varBirth defects researchSurvival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study.PMC11548799CC999999P30 CA086862U01 DD001036Nembhard WNFundora MPOster MERomitti PAAiles ECDesrosiers TACarmichael SLOlshan AFFisher SCF Liberman RNational Birth Defects Prevention StudyForestieri NEShumate CfalseSurvival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study.<h4>Background</h4>Critical congenital heart defects (CCHDs) are associated with considerable morbidity and mortality. This study estimated survival of children with nonsyndromic CCHDs and evaluated relationships between exposures of interest and survival by CCHD severity (univentricular or biventricular function).<h4>Methods</h4>This analysis included 4380 infants with CCHDs (cases) born during 1999-2011 and enrolled in the National Birth Defects Prevention Study, a multisite, population-based case-control study of major birth defects. Cases were linked to state death files. Nonparametric Kaplan-Meier survival functions were used to estimate 1- and 5-year survival probabilities overall and by severity group (univentricular/biventricular) stratified by demographic and clinical exposure var2024-01-01T00:00:00Z2024 Sep2025-04-04T14:40:32.828Z2025-04-04T14:40:32.828ZS-EPMC115487993925845310.1002/bdr2.2394