{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yorek M"],"funding":["NIAID NIH HHS","NCI NIH HHS","NIH HHS"],"pagination":["RP101221"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11548877"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote tumor growth and metastasis in various models. However, the specific molecular mechanisms that drive lipid accumulation and tumor progression in TAMs remain largely unknown. Herein, we demonstrated that unsaturated fatty acids (FAs), unlike saturated ones, are more likely to form lipid droplets in murine macrophages. Specifically, unsaturated FAs, including linoleic acids (LA), activate the FABP4/CEBPα pathway, leading to triglyceride synthesis and lipid droplet formation. Furthermore, FABP4 enhances lipolysis and FA utilization by breast cancer cell lines, which promotes cancer cell migration"],"journal":["eLife"],"pubmed_title":["FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis."],"pmcid":["PMC11548877"],"funding_grant_id":["R01AI137324","R01CA180986","R01 CA180986","R01 AI137324","U01 CA272424","U01CA272424"],"pubmed_authors":["Kong M","Sauter ER","Hao J","Shao J","Yorek M","Liu S","Yu J","Kanagasabapathy A","Curry M","Xiong Y","Sugg SL","Keen H","Liu Z","Avellino A","Jiang X","Li B"],"additional_accession":[]},"is_claimable":false,"name":"FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis.","description":"A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote tumor growth and metastasis in various models. However, the specific molecular mechanisms that drive lipid accumulation and tumor progression in TAMs remain largely unknown. Herein, we demonstrated that unsaturated fatty acids (FAs), unlike saturated ones, are more likely to form lipid droplets in murine macrophages. Specifically, unsaturated FAs, including linoleic acids (LA), activate the FABP4/CEBPα pathway, leading to triglyceride synthesis and lipid droplet formation. Furthermore, FABP4 enhances lipolysis and FA utilization by breast cancer cell lines, which promotes cancer cell migration","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-16T21:45:41.701Z","creation":"2025-04-06T01:45:44.674Z"},"accession":"S-EPMC11548877","cross_references":{"pubmed":["39513934"],"doi":["10.7554/eLife.101221"]}}