biostudies-literatureUnknown12(11)Streubel MK<h4>Background</h4>Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the development of edema in lipedema subcutaneous adipose tissue. The pathogenesis and molecular processes leading to lipedema have not yet been clarified.<h4>Methods</h4>A whole transcriptome analysis of subcutaneous tissue of lipedema stages I (n = 12), II (n = 9), and III (n = 8) compared with hypertrophied subcutaneous tissue (n = 4) was performed. Further data about hormonal substitution and body morphology were collected. The study is registered at ClinicalTrials.gov (NCT05861583).<h4>Results</h4>We identified several differentialPlastic and reconstructive surgery. Global opene6288https://www.ebi.ac.uk/biostudies/studies/S-EPMC11548906biostudies-literatureTranscriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain.PMC11548906Meier-Vollrath IFrambach YStreubel MKBrandenburger MBaumgartner AKisch TfalseTranscriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain.<h4>Background</h4>Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the development of edema in lipedema subcutaneous adipose tissue. The pathogenesis and molecular processes leading to lipedema have not yet been clarified.<h4>Methods</h4>A whole transcriptome analysis of subcutaneous tissue of lipedema stages I (n = 12), II (n = 9), and III (n = 8) compared with hypertrophied subcutaneous tissue (n = 4) was performed. Further data about hormonal substitution and body morphology were collected. The study is registered at ClinicalTrials.gov (NCT05861583).<h4>Results</h4>We identified several differential2024-01-01T00:00:00Z2024 Nov2026-06-01T15:13:03.953Z2026-04-08T13:36:16.521ZS-EPMC115489063952588710.1097/GOX.0000000000006288